Skip to main content

Effects of Phosphatidylserine in Age-Associated Memory Impairment and Alzheimer’s Disease

  • Chapter
Treatment of Dementias

Part of the book series: Advances in Behavioral Biology ((ABBI,volume 40))

  • 96 Accesses

Abstract

Multiple neurotransmitter deficits have been implicated in “normal” age-related memory loss, or AAMI, 1 and in Alzheimer’s disease.2 For example, cognitive deficits seen in these conditions have been related to changes in cholinergic, noradrenergic, and serotonergic function.3-5 Age-related changes in cellular metabolism may play an important role as well.6

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

eBook
USD 16.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Crook T, Bartus RT, Ferris, SH, Whitehouse P, Cohen GD, Gershon S. Age-Associated Memory Impairment: Proposed diagnostic criteria and measures of clinical change — Report of a National Institute of Mental Health Work Group. Dev Neuropsychol 1986; 2: 261–276.

    Article  Google Scholar 

  2. Gottfries CG. Alzheimer’s disease and senile dementia: Biochemical characteristics and aspects of treatment. Psychopharmacology 1985; 86: 245–252.

    Article  PubMed  CAS  Google Scholar 

  3. Altman HJ, Normile HG. What is the nature of the role of the serotonergic nervous system in learning and memory: Prospects for development of an effective treatment strategy for senile dementia. Neurobiol Aging 1988; 9: 627–638.

    Article  PubMed  CAS  Google Scholar 

  4. Battus RT, Dean RL, Beer B, Lippa AS. The cholinergic hypothesis of geriatric memory dysfunction. Science 1982: 217: 408–417.

    Article  Google Scholar 

  5. McEntee WJ, Crook TH. Age-Associated Memory Impairment: A role for catecholamines. Neurology 1990; 40: 526–530.

    Article  PubMed  CAS  Google Scholar 

  6. Battus RT. Drugs to treat age-related neurodegenerative problems. J Am Geriatr Soc 1990; 38: 1–16.

    Google Scholar 

  7. Sun AY, Sun GY. Neurochemical aspects of the membrane hypothesis of aging. Interdiscipl Topics Gerontol 1979; 15: 34–53.

    CAS  Google Scholar 

  8. Schroeder F. Role of membrane lipid asymmetry in aging. Neurobiol Aging 1984; 5: 323–333.

    Article  PubMed  CAS  Google Scholar 

  9. Calderini G, Aporti F, Bellini F, Bonetti AC, Rubini R, Teolato S, Xu C., Zanotti A, Toffano G. Phospholipids as a pharmacological tool in the aging brain. In: Horrocks LA, Kanfer JN, Porcellati G, eds. Phospholipids in the Nervous System, Vol 2, Physiological Roles. New York: Raven Press, 1985.

    Google Scholar 

  10. Caffarra P, Santamaria V. The effects of phosphatidylserine in patients with mild cognitive decline — An open trial. Clin Trials J 1987; 24: 109–114.

    Google Scholar 

  11. Sinforiani E, Agostinis C, Merlo P, Gualtieri S, Mauri M, Mancuso A. Cognitive decline in ageing brain: Therapeutic approach with phosphatidylserine. Clin Trials J 1987; 24: 115–124.

    Google Scholar 

  12. Allegro L, Favaretto V, Ziliotto G. Oral phosphatidylserine in elderly patients with cognitive deterioration: An open study. Clin Trials J 1987; 24: 104–108.

    Google Scholar 

  13. Delwaide PJ, Gysetynck-Mambourg AM, Hurlet A, Ylieff M. Double-blind randomized controlled study of phosphatidylserine in senile demented patients. Acta Neurol Scand 1986; 73:136140.

    Google Scholar 

  14. Palmieri G, Palmieri R, Inzoll MR, Lombardi G, Scottini C., Tavolato B, Giometto B. Double-blind controlled trial of phosphatidylserine in patients with senile mental deterioration. Clin Trials J 1987; 24: 73–83.

    Google Scholar 

  15. Amaducci L and the SMID Group. Phosphatidylserine in the treatment of Alzheimer’s disease: Results of a multicenter study. Psychopharmacol Bull 1988; 24: 130–134.

    PubMed  CAS  Google Scholar 

  16. Villardita C., Grioli S, Salmeri G, Nicoletti F, Pennisi G. Multicentre clinical trial of brain phosphatidylserine in elderly patients with intellectual deterioration. Clin Trials J 1987; 24: 84–93.

    Google Scholar 

  17. Crook TH, Larrabee GJ. Age-Associated Memory Impairment: Diagnostic criteria and treatment strategies. Psychopharmacol Bull 1988; 24: 509–514.

    PubMed  CAS  Google Scholar 

  18. Benton AL. The Revised Visual Retention Test: Clinical and Experimental Applications. New York: Psychological Corporation, 1963.

    Google Scholar 

  19. Wechsler D, Stone CP. Manual: Wechsler Memory Scale. New York: Psychological Corporation, 1983.

    Google Scholar 

  20. Wechsler D. Wechsler Adult Intelligence Scale. Manual. New York: Psychological Corporation, 1955.

    Google Scholar 

  21. Folstein MF, Folstein SE, McHugh PR. “Mini-Mental State”: A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 1975; 12:189– 198.

    Google Scholar 

  22. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders 3rd Edition. Washington, DC, 1980.

    Google Scholar 

  23. Rosen WG, Terry RD, Fuld PA, Katzman R, Peck A. Pathological verification of ischemic score in differentiation of dementias. Ann Neurol 1980; 7: 486–488.

    Article  PubMed  CAS  Google Scholar 

  24. Hamilton M. Development of a rating scale for primary depressive illness. Br J Soc Clin Psychol 1967; 6: 278–296.

    Article  PubMed  CAS  Google Scholar 

  25. Crook TH, Johnson BA, Larrabee GJ. Evaluation of drugs in Alzheimer’s disease and Age-Associated Memory Impairment. In: Benkert O, Maier W, Rickels K, eds. Methodology of the Evaluation of Psychotropic Drugs. Berlin Heidelberg: Springer-Verlag, 1990: 37–55.

    Chapter  Google Scholar 

  26. Crook T, Johnson B, Youniss E, Kelly A, Zadeik A, Bahar H. Behavioral consequences of normal cerebral aging. In: Maloine SA, ed. L’Vieillisenemt Cerebral Normal Et Pathologique. Paris: Foundation Nationale De Gerontologie, 1988: 12–21.

    Google Scholar 

  27. Crook TH, Larrabee GJ. Interrelationships among everyday memory tests: Stability of factor structure with age. Neuropsychology 1988; 2: 1–12.

    Google Scholar 

  28. Larrabee GJ, Crook TH. Dimensions of everyday memory in AgeAssociated Memory Impairment. Psychological Assessment: J Consult Clin Psychol 1989; 1: 92–97.

    Google Scholar 

  29. Larrabee GJ, Crook TH. A computerized everyday memory battery for assessing treatment effects. Psychopharmacol Bull 1988; 24: 695–697.

    PubMed  CAS  Google Scholar 

  30. Crook T, Salama M, Gobert J. A computerized test battery for detecting and assessing memory disorders. In: Bes A, Cahn J, Hoyer S, Marc-Vergnes JP, Wisniewski AM, eds. Senile Dementia: Early Detection London-Paris: John Libbey, 1986: 79–85.

    Google Scholar 

  31. SPSS/PC+ V2.0 Base Manual. Chicago, IL: SPSS, Inc., 1988.

    Google Scholar 

  32. Larrabee GJ, Crook TH. Performance subtypes of everyday memory function. Dev Neuropsychol 1989; 5: 267–283.

    Article  Google Scholar 

  33. BMDP Statistical Software Manual. Berkeley, CA: University of California Press, 1988.

    Google Scholar 

  34. Crook TH, Larrabee GJ. A self-rating scale for evaluating memory in everyday life. Psychol Aging 1990; 5: 48–57.

    Article  PubMed  Google Scholar 

  35. Kral VA. Senescent forgetfulness: Benign and malignant. J Can Med Assoc 1962; 86: 257–260.

    CAS  Google Scholar 

  36. Kral VA. Memory loss in the aged. Dis Nerv Syst 1966; 27 (Suppl.): 51–54.

    Google Scholar 

  37. Reisberg B, Ferris SH, De Leon MJ, Sinaiko E, Fransen E, Kluger A, Mir P, Borenstein J, George AE, Shulman E, Steinberg G, Cohen J. Stage-specific behavioral, cognitive, and in vivo changes in community residing subjects with Age-Associated Memory Impairment and Primary Degenerative Dementia of the Alzheimer type. Drug Dev Res 1988; 15: 101–114.

    Article  Google Scholar 

  38. Crook TH, West RL. Name recall performance across the adult life span. Br J Psychol 1990; 81: 335–349.

    Article  PubMed  Google Scholar 

  39. McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM. Clinical diagnosis of Alzheimer’s disease: Report of the NINCDS-ADRDA work group under the auspices of the Department of Health and Human Services Task Force on Alzheimer’s disease. Neurol 1984; 34: 939–944.

    Article  CAS  Google Scholar 

  40. Eslinger PJ, Damasio AR, Benton AL, Van Allen M. Neuropsychologic detection of abnormal mental decline in older persons. J Amer Med Assoc 1985; 253: 670–674.

    Article  CAS  Google Scholar 

  41. Storandt M, Botwinick J, Danzinger WL, Berg L, Hughes CP. Psychometric differentiation of mild senile dementia of the Alzheimer type. Arch Neurol 1984; 41: 497–499.

    Article  PubMed  CAS  Google Scholar 

  42. Reisberg B, Ferris SH, de Leon MJ, Crook T. The Global Deterioration Scale for the assessment of primary degenerative dementia. Amer J Psychiatry 1982; 139(9): 1136– 1139.

    Google Scholar 

  43. Feher EP, Mahurin RK, Inbody SB, Crook TH, Pirozzolo FJ. Anosognosia in Alzheimer’s disease. Neuropsych, Neuropsychol Behav Neurol 1991; 4: 136–146.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1992 Springer Science+Business Media New York

About this chapter

Cite this chapter

Crook, T.H. et al. (1992). Effects of Phosphatidylserine in Age-Associated Memory Impairment and Alzheimer’s Disease. In: Meyer, E.M., Simpkins, J.W., Yamamoto, J., Crews, F.T. (eds) Treatment of Dementias. Advances in Behavioral Biology, vol 40. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3432-7_17

Download citation

  • DOI: https://doi.org/10.1007/978-1-4615-3432-7_17

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6518-1

  • Online ISBN: 978-1-4615-3432-7

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics