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Delayed Neuronal Death of Hippocampus (CA1) After Transient Global Ischemia: Does Nerve Growth Factor Protect Neurons Against “Killer Proteins” ?

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Book cover Treatment of Dementias

Part of the book series: Advances in Behavioral Biology ((ABBI,volume 40))

Abstract

Specific regions of brain are known to be especially vulnerable to various insults such as ischemia [Spielmeyer, 1925; Brown and Brierley, 1968]. Patients resuscitated from cardiac arrest often suffer from memory impairment. Even a short cessation of cerebral circulation causes damage to the hippocampus, which is critical to memory function [Brierly and Graham, 1984; Petito, 1984]. Delayed neuronal death of the hippocampus was originally described in rodents model of transient global ischemia [Ito et al. 1975; Kirino, 1982; Pulsinelli et al. 1982]. In gerbils, only 5 minutes of bilateral carotid artery occlusion causes selective neuronal death of the hippocampal CAl sector [Kirino, 1982].

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Author information

Authors and Affiliations

  1. Dept. of Neurosurgery, University of Tokyo, Bunkyo, Tokyo, 113, Japan

    Tatsuo Mima & Kintomo Takakura

  2. Dept. of Molecular Biology, Gifu Pharmaceutical University, Gifu, 502, Japan

    Shoei Furukawa & Yoshihide Hashimoto

  3. Dept. of Neuroanatomy, Chiba College of Health Science, Chiba, 260, Japan

    Gunshiro Kato

  4. Hanno Research Center of Taiho Pharmaceutical, Ltd., Saitama, 357, Japan

    Yasundo Yamasaki

  5. Dept. of Neurosurgery, Saitama Medical Center, Kawagoe, Saitama, 350, Japan

    Taku Shigeno

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  1. Tatsuo Mima
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  2. Kintomo Takakura
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  3. Shoei Furukawa
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  4. Yoshihide Hashimoto
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  5. Gunshiro Kato
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  6. Yasundo Yamasaki
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  7. Taku Shigeno
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Editor information

Editors and Affiliations

  1. University of Florida, Gainesville, Florida, USA

    Edwin M. Meyer , James W. Simpkins  & Fulton T. Crews ,  & 

  2. Taiho Pharmaceutical Company, Tokushima, Japan

    Jyunji Yamamoto

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© 1992 Springer Science+Business Media New York

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Mima, T. et al. (1992). Delayed Neuronal Death of Hippocampus (CA1) After Transient Global Ischemia: Does Nerve Growth Factor Protect Neurons Against “Killer Proteins” ?. In: Meyer, E.M., Simpkins, J.W., Yamamoto, J., Crews, F.T. (eds) Treatment of Dementias. Advances in Behavioral Biology, vol 40. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3432-7_13

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  • DOI: https://doi.org/10.1007/978-1-4615-3432-7_13

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6518-1

  • Online ISBN: 978-1-4615-3432-7

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