Abstract
Nerve growth factor (NGF) promotes the maintenance of function and survival of adult cholinergic neurons of the septo-hippocampal pathway and attenuates lesion-induced deficits in neurochemical and behavioral measures related to cholinergic septo-hippocampal functions (Hefti et al., 1984; Will and Hefti, 1985; Williams et al, 1986, 1989; Will et al., 1988, 1990; Lapchak and Hefti, 1991).
Keywords
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
Araujo, D.M., Lapchak, P.A., Robitaille, Y., Gauthier, S. and Quirion, R., 1988, Differential alteration of various cholinergic markers in cortical and sub-cortical regions of the human brain in Alzheimer’s disease. J. Neurochem., 50: 1914.
Arendt, T., Bigl, B., and Tennstedt, A., 1983, Loss of neurons in the nucleus basalis of Meynert in Alzheimer’s disease, paralysis agitans and Korsakoff s disease. Acta Neuropathol., 61: 101.
Bartus, R., Dean, R.L. III, Beer, B., and Lippa, A.S., 1982, The cholinergic hypothesis of geriatric memory dysfunction. Science, 217: 408.
Bradford, M., 1976, A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein dye binding. Anal. Biochem., 72: 248.
Candy, J.M., Perry, E.K., Perry, R.H., Court, J.A., Oakley, A.E., and Edwardson, J.A., 1986, The current status of the cortical cholinergic system in Alzheimer’s disease and Parkinson’s disease, In “Progress in Brain Research”, Vol. 70, D.F. Swaab, E. Fliers, M. Mirmiram, W.A. Van Gool, and F. Van Haaren eds, pp. 105–132, Elsevier Science Publishers B.V., London.
Cavicchioli, L., Flanigan, T.P., Dickson, J.G., Vantini, G., Dal Toso, R., Fusco, M., Walsh, F.S., and Leon, A., 1991, Choline acetyltransferase messenger RNA expression in developing and adult rat brain: regulation by nerve growth factor. Mol. Brain Res., 9: 319.
Collerton, D., 1986, Cholinergic function and intellectual decline in Alzheimer’s disease. Neuroscience, 19: 1.
Hagg, T., Fass-Holmes, B., Vahlsing, H.L., Manthorpe, N., Conner, J.M., and Varon, S., 1989, Nerve growth factor (NGF) reverses axotomy-induced decreases in choline acetyltransferase, NGF receptor and size of medial septum cholinergic neurons. Brain Res., 505: 29.
Hefti, F., Dravid, A., and Hartikka, J., 1984, Chronic intraventricular injections of nerve growth factor elevate hippocampal choline acetyltransferase activity in adult rats with partial septo-hippocampal lesions. Brain Res., 293: 305.
Hefti, F., 1986, Nerve growth factor promotes survival of septal cholinergic neurons after fimbrial transections. J. Neurosci., 6: 2155.
Hefti, F. and Mash, D.C., 1989, Localization of nerve growth factor receptors in the normal human brain and in Alzheimer’s disease. Neurobiol. Aging, 10: 75.
Jenden, D.J., Roch, M. and Booth, R.A., 1973, Simultaneous measurement of endogenous and deuterium labeled tracer variants of choline and acetylcholine in subpicomole quantities by gas chromatography/mass spectrometry. Anal. Biochem., 55: 438.
Koenig, J.F.R., and Klippel, R.A., 1963, The rat brain. A stereotaxic atlas of the forebrain and lower parts of the brain stem. Williams and Wilkins, Baltimore, MD.
Koliatsos, V.E., Applegate, M.D., Knusel, B., Junard, E.O., Burton, G., Mobley, W.C., Hefti, F.F. and Price D.L., 1990, Human recombinant nerve growth factor prevents retrograde degeneration of axotomized basal forebrain cholinergic neurons in the rat. Exp. Neurol., 112: 161.
Kordower, J.H., Gash, D.M., Bothwell, M., Hersh, L., and Mufson, E.J., 1989, Nerve growth factor receptor and choline acetyltransferase remain colocalized in the nucleus basalis (Ch4) of Alzheimer’s patients. Neurobiol. Aging, 10: 67.
Lapchak, P.A. and Collier, B., 1988, Vasoactive intestinal peptide increases acetylcholine synthesis by rat hippocampal slices. J. Neurochem., 50: 58.
Lapchak, P.A., and Hefti, F., 1991, Effect of recombinant human nerve growth factor on presynaptic cholinergic function in rat hippocampal slices following partial septo-hippocampal lesions: measures of [3H]acetylcholine synthesis, [3H]acetylcholine release and choline acetyltransferase activity. Neuroscience, 42: 639.
Montero, C.N. and Hefti, F., 1988, Rescue of lesioned septal cholinergic neurons by nerve growth factor: specificity and requirement for chronic treatment. J. Neurosci., 8: 2986.
Mufson, E.J., Bothwell, M., Hersh, L.B., and Kordower, J.H., 1989, Nerve growth factor receptor immunoreactive profiles in the normal, aged human basal forebrain: colocalization with cholinergic neurons. J. Comp. Neurol., 285: 196.
Perry, E., Tomlinson, B.E., Blessed, G., Bergmann, K., Gibson, P.H., and Perry, R.H., 1978, Correlation of cholinergic abnormalities with senile plaques and mental test scores in senile dementia. Br. Med. J., 2: 1457.
Rylett, R.T., Ball, M.J., and Colhoun, E.H., 1983, Evidence for high affinity choline transport in synaptosomes prepared from hippocampus and neocortex of patients with Alzheimer’s disease. Brain Res., 289: 169.
Sims, N.R., Bowen, D.M., Smith, C.C.T., Flock, R.H.A., Davison, A.N., Snowden, J.S., and Neary, D., 1980, Glucose metabolism and acetylcholine synthesis in relation to neuronal activity in Alzheimer’s disease. Lancet, I: 333.
Slotkin, T.A., Seidler, F.J., Crain, B.J., Bell, J.M., Bissette, G., and Nemeroff, C.B., 1990, Regulatory changes in presynaptic cholinergic function assesses in rapid autopsy material from patients with Alzheimer’s disease: Implications for etiology and therapy. Proc. Natl. Acad. Sci., USA, 87: 2452.
Whitehouse, P.J., Price, D.L., Struble, R.G., Clark, A.W., Coyle, J.T., and Delong, M.R., 1982, Alzheimer’s disease and senile dementia: Loss of neurons in the basal forebrain. Science, 215: 1237.
Will, B. and Hefti, F., 1985, Behavioural and neurochemical effects of chronic intraventricular injections of nerve growth factor in adult rats with fimbrial lesions. Behav. Brain Res., 17: 17.
Will, B., Hefti, F., Pallage, V., and Toniolo, G., 1988, Nerve growth factor, Effect on CNS neurons and on behavioral recovery from brain damage, In “Pharmacological Approaches to the Treatment of Brain and Spinal Cord Injury” pp. 339–360. Plenum Press, New York.
Will, B., Pallage, V., and Eclancher, F., 1990, Nerve growth factor and behavioral recovery after brain damage in rats, In “Neurotrophic Factors and Alzheimer’s Disease” pp 117–130, Springer, New York.
Williams, L.R., Jodelsi, K.S., and Donald, M.R., 1989, Axotomy-dependent Stimulation of choline acetyltransferase activity by exogenous mouse nerve growth factor in adult rat basal forebrain. Brain Res., 498: 243.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1992 Springer Science+Business Media New York
About this chapter
Cite this chapter
Lapchak, P.A., Hefti, F. (1992). Recombinant Human Nerve Growth Factor Increases Presynaptic Cholinergic Function Following Neuronal Damage: Implications for the Treatment of Alzheimer’s Disease. In: Meyer, E.M., Simpkins, J.W., Yamamoto, J., Crews, F.T. (eds) Treatment of Dementias. Advances in Behavioral Biology, vol 40. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3432-7_12
Download citation
DOI: https://doi.org/10.1007/978-1-4615-3432-7_12
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-6518-1
Online ISBN: 978-1-4615-3432-7
eBook Packages: Springer Book Archive