Abstract
In cases of severe hemorrhagic shock small volumes of hypertonic-hyperoncotic solutions (HHS) are efficient in restoring cardiovascular function immediately (1–3). While the macrocirculatory changes following infusion of HHS after hemorrhagic shock are well understood (4–6), little is known about the effects of this treatment on the central nervous system in particular in the presence of cerebral injury comprising deleted autoregulation and brain edema (7). We have, therefore, investigated the changes in oxygen supply of the brain in the presence of a cryogenic lesion after hemorrhagic shock and infusion of 7.2% NaCl/10% Dextran 60.
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References
Smith G.J., Kramer G.C., Perron P., Nakayama S.I., Gunther R.A., and Holcroft J.W., 1985, A comparison of severel hypertonic solutions for resuscitation of bled sheep, J. Surg. Res., 39: 517–528.
Kramer G.C., Perron P.R., Lindsey D.C., Ho H.S., Gunther R.A., Boyle W.A. and Holcroft J.W., 1986, Small volume resuscitation with hypertonic saline dextran solution Surgery 100: 239–247.
Kreimeier U. and Messmer K., 1988, Small volume resuscitation with hypertonic-hypverosmotic solutions — state of the art review, In Fluid Resuscitation, W. Kox, J. Gamble, Eds., Ballière’s Clinical Anaesthesiology: 545–577
Hannon J.P., Wade C.E., Bossone C.A., Hunt M.M., Coppes R.I. and Loveday J.A., 1987, Effects of 7,5% NaC1/6% Dextran on oxygen transport and demand in conscious swine subjected to hemorrhagic hypotension, The Physiologist, 30: 229
Mazzoni M.C., Borgstroem P., Arfors K.E. and Intaglietta M., 1988, Dynamic fluid distribution in hyperosmotic resuscitation of hypovolemic hemorrhage, Am. J. Physiol, 255: h629 - h637
Rochae Silva M., Negraes G.A., Soares A.M., Pontieri V., and Loppnow L., 1986, Hypertonic resuscitation from severe hemorrhagic shock: Patterns of regional circulation. Circ. Shock 19: 165–175.
Gunnar W.P., Merlotti G.J., Jonasson O., Barrett J., 1986, Resuscitation from hemorrhagic shock. Alterations of the intracranial pressure after normal saline, 3% saline and dextran 40, Ann. Surg., 204 (6): 686–692
Kessler M., Höper J. und Krumme B.A., 1976, Monitoring of tissue perfusion and cellular function. Anesthesiology 45: 184–197
Klatzo I., Piraux A., Laskowski E.J., 1958, The relationship between edema, blood brain barrier and tissue elements in a local brain injury, J. Neuropathol. Exp. Neurol. 17: 548–564
Lübbers D.W., 1972, Physiology der Gehirndurchblutung. in Der Gehirnkreislauf. Physiologie, Pathologie, Klinik. Gänshirt H., ed., Georg Thieme Stuttgard, 214–260
Maekawa T., McDowall D.G. and Okuda Y., 1979, Brain surface oxygen tension and cerebral cortical blood flow during hemorrhagic and drug induced hypotension in the cat, Anesthesiol., 51: 313–320
Kozniewska E., Weller L., Höper J., Harrison D.K. and Kessler M., 1987, Cerebrocortical microcirculation in different stages of hypoxic hypoxia, J. Cereb. Blood Flow Metab., 7: 464–470
Ivanov K.P., Kislanov Y.Y. and Samoilov M.O., 1979, Microcirculation and transport of oxygen to neurons of the brain, Microvasc. Res., 18: 434–446
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Dautermann, C., Schürer, L., Härtl, R., Röhrich, F., Baethmann, A., Messmer, K. (1992). Treatment of Hemorrhagic Hypotension with Hypertonic Saline/Dextran: Effects on Brain Surface Oxygen Tension in Experimentally Traumatized Brain. In: Erdmann, W., Bruley, D.F. (eds) Oxygen Transport to Tissue XIV. Advances in Experimental Medicine and Biology, vol 317. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3428-0_88
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DOI: https://doi.org/10.1007/978-1-4615-3428-0_88
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