Abstract
The fundamental question as to how erythrocyte transit time and flow path length ensure adequate oxygen extraction from blood during compromised blood supply or increased cerebral metabolic rate is still unanswered. A longer mean transit time would allow more complete deoxygenation of the arterial blood, however, it would attenuate the diffusion gradient of oxygen tension in the tissue. The importance of optimal erythrocyte flow path length for oxygen transport may be reflected in the characteristic tortuous pattern of cerebral capillaries (Wiederhold et al, 1976), which is different in various cytoarchitectural layers of the cerebral cortex (Duvernoy et al, 1981). Tortuosity may play a role in the prolongation of transit time to compensate for the high velocity of erythrocytes in cerebrocortical capillaries.
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Hudetz, A.G. (1992). Computer Simulation of Erythrocyte Transit in the Cerebrocortical Capillary Network. In: Erdmann, W., Bruley, D.F. (eds) Oxygen Transport to Tissue XIV. Advances in Experimental Medicine and Biology, vol 317. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3428-0_79
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DOI: https://doi.org/10.1007/978-1-4615-3428-0_79
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