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Computerized Histographic Oxygen Tension Measurements of Murine Tumors

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Oxygen Transport to Tissue XIV

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 317))

Abstract

As further work on tumor oxygenation results in the development of agents capable of modulating hypoxic cell radiosensitivity, and chemotherapeutic agents capable of targeting hypoxic cells, knowledge of relative tumor oxygenation takes on greater importance.

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References

  1. Gray LH, Conger AD, Ebert M, Hornsey S, Scott OC, 1953, Concentration of oxygen dissolved in tissues at the time of irradiation as a factor in radiotherapy. Brit J Radiol, 26: 638–648.

    Article  PubMed  CAS  Google Scholar 

  2. Garrecht BM, Chapman JD, 1983, The labelling of EMT-6 tumours in BALB/C mice with 14C-misonidazole. Brit J Radiol. 56: 745–753.

    Article  PubMed  CAS  Google Scholar 

  3. Okunieff P, Vaupel P, Sedlacek R, Neuringer LJ, 1989, Evaluation of tumor energy metabolism and microvascular blood flow after glucose or mannitol administration using 31P nuclear magnetic resonance spectroscopy and laser Doppler flowmetry. Int J Rad Oncol Biol Phys. 16: 1493–1500.

    Article  CAS  Google Scholar 

  4. Vaupel P, Kluge M, Ambroz MC, 1988, Laser doppler flowmetry in subepidermal tumours and in normal skin of rats during localized ultrasound hyperthermia. Int J Hyperthermia. 3: 307–321.

    Article  Google Scholar 

  5. Urbach F, 1956, Pathophysiology of malignancy: I. Tissue oxygen tension of benign and malignant tumors of the skin. Proc Soc Exp Biol Med. 92: 644–649.

    PubMed  CAS  Google Scholar 

  6. Cater DB, Silver IA, 1960, Quantitative measurements of oxygen tension in normal tissues and in the tumours of patients before and after radiotherapy. Acta Radiol. 53: 233–256.

    Article  PubMed  CAS  Google Scholar 

  7. Badib AO, Webster JH, 1969, Changes in tumor oxygen tension during radiation therapy. Acta Rad Ther Phys Biol. 8: 247–257.

    CAS  Google Scholar 

  8. Vaupel P, Kallinowski F, Okunieff P, 1989, Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: a review. Cancer Res. 49: 6449–6465.

    PubMed  CAS  Google Scholar 

  9. Kallinowski F, Schlenger KH, Runkel S, Kloes M, Stohrer M, Okunieff P, Vaupel P, 1989, Blood flow, metabolism, cellular microenvironment, and growth rate of human tumor xenografts. Cancer Res. 49: 3759–3764.

    PubMed  CAS  Google Scholar 

  10. Mueller-Klieser WF, Walenta SM, Kallinowski F, Vaupel PW, 1989, Tumor physiology and cellular microenvironments, in: “Prediction of tumor treatment response,” JD Chapman, LJ Peters, HR Withers, eds., Pergamon Press, Elmsford, NY.

    Google Scholar 

  11. Davies PW, Brink F, 1942, Microelectrodes for measuring local oxygen tension in animal tissues. Rev Sci Instrum. 13: 524–533.

    Article  CAS  Google Scholar 

  12. Gatenby RA, Kessler HB, Rosenblum JS, Coia LR, Moldofsky PJ, Hartz WH, Broder GJ, 1988, Oxygen distribution in squamous cell carcinoma metastases and its relationship to outcome of radiation therapy. Int J Rad Oncol Biol Phys. 14: 831–838.

    Article  CAS  Google Scholar 

  13. Fleckenstein W, Weiss C, Heinrich R, Schomerus H, Kersting T, 1984, A new method for the bed-side recording of tissue pO2-Histograms. Verh Dtsch Ges Inn Med. 90: 439–443.

    Google Scholar 

  14. Kallinowski F, Zander R, Hoeckel M, Vaupel P, 1990, Tumor tissue oxygenation as evaluated by computerized-pO2-histography. Int J Rad Oncol Biol Phys. 19: 953–961.

    Article  CAS  Google Scholar 

  15. Dische S, 1985, Chemical sensitizers for hypoxic cells: A decade of experience in clinical radiotherapy. Radiotherapy Oncol. 3: 97–115.

    Article  CAS  Google Scholar 

  16. Brown JM, 1982, Clinical perspectives for the use of new hypoxic cell sensitizers. Int J Rad Oncol Biol Phys. 8: 1491–1497.

    Article  CAS  Google Scholar 

  17. Zeman EM, Brown JM, Lemmon MJ, Kirst VK, Lee WW, 1986, SR-4233: a new bioreductive agent with high selective toxicity for hypoxic mammalian cells. Int J Rad Oncol Biol Phys. 12: 1239–1242.

    Article  CAS  Google Scholar 

  18. Vaupel P, Okunieff P, Kallinowski F, Neuringer LJ, 1989, Correlations between 31P-NMR spectroscopy and tissue O2 tension measurements in a murine fibrosarcoma. Radiat Res. 120: 477–493.

    Article  PubMed  CAS  Google Scholar 

  19. Kitakabu Y, Shibamoto Y, Sasai K, Ono K, Abe M, 1991, Variations of the hypoxic fraction in the SCCVII tumors after single dose and during fractionated radiation therapy: assessment without anesthesia or physical restraint of mice. Int J Rad Oncol Bio Phys. 20: 709–714.

    Article  CAS  Google Scholar 

  20. Moulder JE, Rockwell S, 1984, Hypoxic fractions of solid tumors: experimental techniques, methods of analysis, and a survey of existing data. Int J Rad Oncol Biol Phys. 10: 695–612.

    Article  CAS  Google Scholar 

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© 1992 Springer Science+Business Media New York

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Terris, D.J., Minchinton, A.I., Dunphy, E.P., Brown, J.M. (1992). Computerized Histographic Oxygen Tension Measurements of Murine Tumors. In: Erdmann, W., Bruley, D.F. (eds) Oxygen Transport to Tissue XIV. Advances in Experimental Medicine and Biology, vol 317. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3428-0_15

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  • DOI: https://doi.org/10.1007/978-1-4615-3428-0_15

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6516-7

  • Online ISBN: 978-1-4615-3428-0

  • eBook Packages: Springer Book Archive

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