Abstract
Various lipids have been implicated in signal transduction and as precursors of lipid mediators, among them arachidonic acid (Dennis et al., 1991). Production of the prostaglandins, thromboxanes, and prostacyclins via the cyclooxygenase pathway, as well as the production of the leukotrienes and lipoxins via the lipoxygenase pathway, all depend on the availability of free arachidonic acids. As illustrated in Figure 1, control of the production of free arachidonic acid is believed to involve an as yet undefined membrane receptor event (Dennis, 1989). Presumably this event involves the activation of a phospholipase, either directly or through mediators. Presumably this phospholipase is membrane associated or becomes so after translocation (Channon and Leslie, 1990). Because the bulk of cellular arachidonic acid is found esterified in the sn-2position of membrane phospholipids, a phospholipase A2 is the simplest and most logical enzyme
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References
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© 1992 Springer Science+Business Media New York
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Dennis, E.A., Deems, R.A., Yu, L. (1992). Extracellular Phospholipase A2 . In: Bazan, N.G., Murphy, M.G., Toffano, G. (eds) Neurobiology of Essential Fatty Acids. Advances in Experimental Medicine and Biology, vol 318. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3426-6_4
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DOI: https://doi.org/10.1007/978-1-4615-3426-6_4
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