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Physical Mapping of Human Chromosomes

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Book cover Genetic Engineering

Part of the book series: Genetic Engineering ((GEPM,volume 14))

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Abstract

A major focus of modern molecular biology is the isolation and analysis of genes based upon associated phenotypes. The strategies for “positional cloning,” where a gene is cloned, analyzed and the basic underlying biology uncovered based upon its chromosomal map location alone, form the basis of much modern molecular genetics research and has made possible the isolation, characterization and understanding of genes responsible for many human hereditary, malignant and degenerative diseases. The success of this type of phenotype-based gene hunting has been dramatically illustrated through the cloning of genes responsible for Duchenne’s muscular dystrophy (1), cystic fibrosis (2) and neurofibromatosis type 1 (3), among many others.

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Author information

Authors and Affiliations

  1. Molecular Genetics Laboratory and Center for Human Genome Research, The Salk Institute for Biological Studies, La Jolla, CA, 92037, USA

    Glen A. Evans & David L. McElligott

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  1. Glen A. Evans
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  2. David L. McElligott
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Editors and Affiliations

  1. Brookhaven National Laboratory, Upton, New York, USA

    Jane K. Setlow

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© 1992 Springer Science+Business Media New York

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Evans, G.A., McElligott, D.L. (1992). Physical Mapping of Human Chromosomes. In: Setlow, J.K. (eds) Genetic Engineering. Genetic Engineering, vol 14. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3424-2_15

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  • DOI: https://doi.org/10.1007/978-1-4615-3424-2_15

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6514-3

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