Abstract
The principle of Boron Neutron Capture Therapy is based on the nuclear reaction that occurs when 10B, a stable isotope, is irradiated with thermal neutrons (0.025 eV neutrons). Particles, emitted from the capture reaction are largely high LET α-particles and lithium-7 particles with a mean free path of 9 µm and 5 µm, respectively. If tumor cells can be selectively loaded with boron containing compounds, unresectable tumors may be eradicated with a high normal tissue tolerance by irradiating the tumor volume with thermalized neutrons from an epithermal (10 keV mean energy) neutron beam. The primary goal in current BNCT research is to examine the therapeutic potential of BNCT for the treatment of grade IV gliomas, although successive objectives include treatment feasibility studies of other tumors, with a main interest in melanomas1,2.
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© 1992 Springer Science+Business Media New York
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Verrijk, R., Huiskamp, R., Smolders, I.J.H., Begg, A.C., Sorber, C.W.J., De Bruijn, W.C. (1992). Cellular Pharmacokinetics of BNCT Compounds and their Cellular Localization with EELS/ESI. In: Gabel, D., Moss, R. (eds) Boron Neutron Capture Therapy. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3408-2_21
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DOI: https://doi.org/10.1007/978-1-4615-3408-2_21
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