Abstract
In a previous communication we have reported the results of a biodistribution study of intravenous borocaptate sodium (BSH) administered to 28 patients undergoing craniotomy for various intracranial tumors10. The measured boron concentrations in tumor, blood, and normal cranial tissues led to the tentative conclusion 1) that BSH readily enters most malignant intracerebral tumors, 2) that some retention of the drug occurs in these tumor, leading to an improvement of the tumor-to-blood ratio over the first 18 hours, and possibly later, and 3) that BSH is virtually excluded from normal brain.
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Fankhauser, H., Stragliotto, G., Zbinden, P. (1992). Borocaptate Sodium (BSH) Pharmacokinetics in Glioma Patients. In: Gabel, D., Moss, R. (eds) Boron Neutron Capture Therapy. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3408-2_17
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DOI: https://doi.org/10.1007/978-1-4615-3408-2_17
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