Abstract
Single dose RBEs for the radiations encountered in BNCT have been determined1 and can provide useful guidance for the tolerance to be expected. The difficulty of microdosimetric determination of dose2, the rapidly varying mix of constituent high and low LET radiations with depth, the possible synergistic interaction between high and low LET radiations3, and the strong dependence of biological efficacy on the distribution of boron within the cell are all factors limiting the usefulness of RBEs. Large animal studies arenecessary to determine late effect tolerance. To design, interpret, compare, and apply these studies to clinical use, it has been proposed to divide factors influencing “RBE” into two groups4; 1) estimated tolerance dose (ETD), which can be inferred from other experience reasonably well; and 2) compound factor (CF), which is much more variable as a function of microdosimetry and boron compound.
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Gahbauer, R.A., Fairchild, R.G., Goodman, J.H., Blue, T.E. (1992). RBE in Normal Tissue Studies. In: Gabel, D., Moss, R. (eds) Boron Neutron Capture Therapy. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3408-2_14
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DOI: https://doi.org/10.1007/978-1-4615-3408-2_14
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