Abstract
A difference in PO2 (ΔPO2) between red cells and tissue cells defines a driving force for diffusive O2 transport. This ΔPO2 depends on the flux and the over-all tissue conductance for O2: VO2 = [PcapO2 - PmbO2] x C equation 1 In the steady state, VO2 (rate of O2 consumption), equals the transcapillary O2 flux. PcapO2 can be defined as mean PO2 in the capillary population. Since diffusive shunting is negligible in red muscle (Honig and Gayeski 1989), effluent venous PO2 is a lower bound on mean PcapO2. PmbO2 is defined as the PO2,in equilibrium with myoglobin (Mb). Measurements of PmbO2 at the center of a cell profile, as in the present report, furnish a lower bound on PmbO2. C in equation 1 is a lumped conductance for O2. This conductance varies inversely and non-linearly with PmbO2.
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Honig, C.R., Connett, R.J., Gayeski, T.E.J. (1992). Interaction of Blood Flow, Diffusive Transport and Cell Metabolism in Isovolemic Anemia. In: Goldstick, T.K., McCabe, M., Maguire, D.J. (eds) Oxygen Transport to Tissue XIII. Advances in Experimental Medicine and Biology, vol 316. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3404-4_3
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