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Nuclear Magnetic Resonance Spectroscopy and the Study of Tissue Oxygen Metabolism: A Review

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Oxygen Transport to Tissue XIII

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 316))

Abstract

Nuclear magnetic resonance (NMR) techniques are being increasingly utilised as an in vivo method to monitor tissue oxygen concentration in various organs. In muscle and heart, proton NMR spectroscopy of myoglobin has been used to calculate local oxygen tension through the oxygen sensitivity of the histidine group signal intensity. Similarly, spin lattice relaxation times of perfluorocarbon emulsions are oxygen sensitive, and this property has been taken advantage of to produce oxygen maps of brain by fluorine NMR imaging. Phosphorus NMR spectroscopy has also been extensively used to monitor bioenergetic state, which under some conditions, is directly related to tissue oxygen tension. This review will focus on these NMR techniques for oxygen determination, and will critically assess their utility for further studies.

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Author information

Authors and Affiliations

  1. Department of Chemistry and Biochemistry, James Cook University of North Queensland, Townsville, Queensland, 4811, Australia

    Robert Vink

Authors
  1. Robert Vink
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Editor information

Editors and Affiliations

  1. Northwestern University, Evanston, Illinois, USA

    Thomas K. Goldstick

  2. University of Kuwait, Sulaibikhat, Kuwait

    Michael McCabe

  3. Griffith University, Brisbane, Queensland, Australia

    David J. Maguire

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© 1992 Springer Science+Business Media New York

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Vink, R. (1992). Nuclear Magnetic Resonance Spectroscopy and the Study of Tissue Oxygen Metabolism: A Review. In: Goldstick, T.K., McCabe, M., Maguire, D.J. (eds) Oxygen Transport to Tissue XIII. Advances in Experimental Medicine and Biology, vol 316. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3404-4_22

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  • DOI: https://doi.org/10.1007/978-1-4615-3404-4_22

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6504-4

  • Online ISBN: 978-1-4615-3404-4

  • eBook Packages: Springer Book Archive

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