Abstract
The intravitreal and intraretinal oxygen distribution has been studied in several larger animals1,2,3 but never before in the rat. In fact the small vitreal volume (55µl)4 and large lens has previously dissuaded attempts at intraocular microelectrode work of any description. However, the advent of several rat models of retinal vascular disease has made this animal an attractive model in which to study retinal oxygenation, with a view to a better understanding of human diseases of a vascular nature. We therefore modified our techniques developed for larger animals to allow comparable measurements to be made in the rat. Vitreal oxygen tension distribution has been determined, with particular attention to the effects of retinal arteries and veins. The intraretinal oxygen tension profIle has also been categorised. The effects of hyperoxic ventilation were also investigated intravitreally and intraretinally. This control data will be vital to our future studies of the effects of vascular impairment in models of vascular disease.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
V.A. Alder, S.J. Cringle, and I.J. Constable, The retinal oxygen profile in cat. Invest. Ophthalmol. Vis. Sci. 24:30–36 (1983).
R.A. Linsenmeier, and C.M. Yancey, Effects of hyperoxia on the oxygen distribution in the intact cat retina. Invest. Ophthalmol. Vis. Sci. 30, 612 (1989).
M. Tsacopoulos, R. Baker, and S. Levy, Studies on retinal oxygenation. Adv Exp Med Biol 75:413 (1976).
A. Chaudhurl, P.E. Hallett, and J.A. Parker, Aspheric curvatures, refractive indices and chromatic aberration for the rat eye. Vis. Res. 23:1351 (1983).
R.A. Linsenmeier, Effects of light and darkness on oxygen consumption and distribution in the cat retina. J Gen Physiol 88:521 (1986).
V.A. Alder, and S.J. Cringle, Intraretinal and preretinal PO2 response to acutely raised intraocular pressure in cats. Am J Physiol. 256 (Heart. Circ. Physiol. 25):H1627 (1989).
V.A. Alder and S.J. Cringle, The effect of the retinal circulation on vitreal oxygen tension. Curr. Eye Res. 4:121 (1985).
C.J. Pournaras, C.E. Riva, M. Tsacopoulos, and K. Strommer, Diffusion of O2 in the retina of anaesthetized miniature pigs in nonnoxia and hyperoxia. Exp. Eye Res. 49:347(1989).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1992 Springer Science+Business Media New York
About this chapter
Cite this chapter
Cringle, S.J., Yu, DY., Alder, V.A. (1992). Intravitreal and Intraretinal Oxygen Tension in the Rat Eye. In: Goldstick, T.K., McCabe, M., Maguire, D.J. (eds) Oxygen Transport to Tissue XIII. Advances in Experimental Medicine and Biology, vol 316. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3404-4_12
Download citation
DOI: https://doi.org/10.1007/978-1-4615-3404-4_12
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-6504-4
Online ISBN: 978-1-4615-3404-4
eBook Packages: Springer Book Archive