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The Interleukin-2 Receptor: A Target for Immunotherapy

  • Thomas A. Waldmann
  • Carolyn Goldman
  • Lois Top
  • Angus Grant
  • Jack Burton
  • Richard Bamford
  • Erich Roessler
  • Ivan Horak
  • Sara Zaknoen
  • Claude Kasten-Sportes
  • Jeffrey White
  • David Nelson
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 323)

Abstract

Immune intervention began almost two centuries ago when Jenner introduced vaccination with cowpox as a means of protecting against smallpox. This form of immune intervention plays a dominant role in the prevention of human disease. Furthermore, immunological approaches including radioimmunoassays, enzyme-linked immunoassays, microfluorometry, and modern molecular immunogenetics are critical in clinical diagnosis.

Keywords

Allograft Rejection Hairy Cell Leukemia Murine Monoclonal Antibody Immune Intervention Mixed Leukocyte Reaction 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    G. Köhler and C. Milstein, Continuous cultures of fused cells secreting antibody of pre-defined specificity, Nature 256:495 (1975).Google Scholar
  2. 2.
    R. Catane and D.L. Longo, Monoclonal antibodies for cancer therapy, Isr. J. Med. Sci. 24:471 (1989).Google Scholar
  3. 3.
    T.A. Waldmann, Multichain interleukin-2 receptor: a target for immunotherapy in lymphoma, J. Natl. Cancer Inst. 81:914 (1989).Google Scholar
  4. 4.
    T.A. Waldmann, The interleukin-2 receptor, J. Biol. Chem. 266:2681 (1991).Google Scholar
  5. 5.
    P.T. Jones, P.H. Dear, J. Foote, M.S. Neuberger, and G. Winter, Replacing the complementarity-determining regions in a human antibody with those from a mouse, Nature 321:522 (1986).Google Scholar
  6. 6.
    C. Queen, W.P. Schneider, H.E. Selick, P.W. Payne, N.F. Landolfi, J.F. Duncan, N.M. Avdalovic, M. Levitt, R.P. Junghans, and T.A. Waldmann, A humanized antibody that binds to the IL-2 receptor, Proc. Natl. Acad. Sci. USA 86:10029 (1989).Google Scholar
  7. 7.
    R.P. Junghans, T.A. Waldmann, N.D. Landolfi, N.M. Avdalovic, W.P. Schneider, and C. Queen, Anti-Tac-H, a humanized antibody that binds the interleukin-2 receptor: a novel agent for immunotherapy in malignant and immune disorders, Cancer Res. 50:1495 (1990).Google Scholar
  8. 8.
    H. Lorberboum-Galski, R. Kozak, T. Waldmann, P. Bailon, D. FitzGerald, and I. Pastan, IL2-PE40 is cytotoxic to cells displaying either the p55 or p75 subunit of the IL-2 receptor, J. Biol. Chem. 263:18650 (1988).Google Scholar
  9. 9.
    V.K. Chaudhary, C. Queen, R.P. Junghans, T.A. Waldmann, D.J. FitzGerald, and I. Pastan, A recombinant immunotoxin consisting of two antibody variable domains fused to Pseudomonas exotoxin, Nature 339:394 (1989).Google Scholar
  10. 10.
    R.W. Kozak, R.W. Atcher, O.A. Gansow, A.M. Friedman, J.J. Hines, and T.A. Waldmann, Bismuth-212 labeled anti-Tac monoclonal antibody: alpha-particle emitting radionuclides as modalities for radioimmunotherapy, Proc. Natl. Acad. Sci. USA 83:474 (1986).Google Scholar
  11. 11.
    R.W. Kozak, A. Raubitschek, S. Mirzadeh, M.W. Brechbiel, R. Junghans, O.A. Gansow, and T.A. Waldmann, Nature of the bifunctional chelating agent used for radioimmunotherapy with yttrium-90 monoclonal antibodies: a critical factor in determining in vivo survival and organ toxicity, Cancer Res. 49:2639 (1989).Google Scholar
  12. 12.
    K.A. Smith, T-cell growth factor, Immunol. Rev. 51:337 (1980).Google Scholar
  13. 13.
    T.A. Waldmann, The structure, function, and expression of interleukin-2 receptors on normal and malignant lymphocytes, Science 232:727 (1986).Google Scholar
  14. 14.
    W.A. Kuziel and W.C. Greene, Interleukin-2 and the IL-2 receptor: new insights into structure and function, J. Invest. Dermatol. 94:27S (1990).Google Scholar
  15. 15.
    R.J. Robb, A. Munck, and K.A. Smith, T cell growth factor receptors. Quantification, specificity, and biological relevance, J. Exp. Med. 154:1455 (1981).Google Scholar
  16. 16.
    T. Uchiyama, S. Broder, and T.A. Waldmann, A monoclonal antibody (anti-Tac) reactive with activated and functionally mature human T cells, J. Immunol. 126:1393 (1981).Google Scholar
  17. 17.
    T. Uchiyama, D.L. Nelson, T.A. Fleischer, and T.A. Waldmann, A monoclonal antibody (anti-Tac) reactive with activated and functionally mature human T cells, Expression of Tac antigen on activated cytotoxic killer T-cells, suppressor cells, and one of two types of helper T cells, J. Immunol. 126:1398 (1981).Google Scholar
  18. 18.
    M. Tsudo, R.W. Kozak, C.K. Goldman, and T.A. Waldmann, Demonstration of a non-Tac peptide that binds interleukin-2: a potential participant in a multichain interleukin 2 receptor complex, Proc. Natl. Acad. Sci. USA 83:9694 (1986).Google Scholar
  19. 19.
    M. Tsudo, R.W. Kozak, C.K. Goldman, and T.A. Waldmann, Contribution of a p75 interleukin-2 binding peptide to a high-affinity interleukin-2 receptor complex, Proc. Natl. Acad. Sci. USA 84:4215 (1987).Google Scholar
  20. 20.
    M. Sharon, R.D. Klausner, B.R. Cullen, R. Chizzonite, and W.J. Leonard, Novel interleukin-2 receptor subunit detected by cross-linking under high-affinity conditions, Science 234:859 (1986).Google Scholar
  21. 21.
    M. Hatakeyama, M. Tsudo, S. Minamoto, T. Kono, T. Doi, T. Miyata, and T. Tomiguchi, Interleukin-2 receptor β chain gene: generation of three receptor fonns by cloned human ∝ and β chain cDNA’s, Science 244:551 (1989).Google Scholar
  22. 22.
    J.F. Bazan, Structural design and molecular evolution of a cytokine receptor superfamily, Proc. Natl. Acad. Sci. USA 87:6934 (1990).Google Scholar
  23. 23.
    J. Szöllösi, S. Damjanovich, C.K. Goldman, M.J. Fulwyler, A.A. Aszalos, G. Goldstein, P. Rao, M.A. Talle, and T.A. Waldmann, Flow cytometric resonance energy transfer measurements support the association of a 95-kDa peptide tenned T27 with the 55-kDa Tac peptide, Proc. Natl. Acad. Sci. USA 84:7246 (1987).Google Scholar
  24. 24.
    M. Sharon, J.R. Gnarra, M. Bamiyash, and W.J. Leonard, Possible association between IL-2 receptors and class I HLA molecules on T cells, J. Immunol. 141:3512 (1988).Google Scholar
  25. 25.
    J. Burton, C.K. Goldmann, P. Rao, M. Moos, and T.A. Waldmann, The association of intercellular adhesion molecule 1 with the multichain high-affinity interleukin-2 receptor, Proc. Natl. Acad. Sci. USA 87:7329 (1990).Google Scholar
  26. 26.
    M. Edidin, A. Aszalos, S. Damjanovich, and T.A. Waldmann, Lateral diffusion measurements give evidence for association of the Tac peptide of the IL-2 receptor with the T27 peptide in the plasma membrane of HUT-102-B2 T cells, J. Immunol. 141:1206 (1988).Google Scholar
  27. 27.
    L.A. Rubin, C.C. Kurman, W.E. Biddison, N.D. Goldman, and D.L. Nelson, A monoclonal antibody 7G7/B6 binds to an epitope on the human interleukin-2 (IL-2) receptor that is distinct from that recognized by IL-2 or anti-Tac, Hybridoma 4:91 (1985).Google Scholar
  28. 28.
    T.A. Waldmann, W.C. Greene, P.S. Sarin, C. Saxinger, D.W. Blayney, W.A. Blattner, C.K. Goldman, K. Bongiovanni, S. Sharrow, J.M. Depper, W. Leonard, T. Uchiyama, and R.C. Gallo, Functional and phenotypic comparison of human T cell leukemia/lymphoma virus positive adult T-cell leukemia with human T-cell leukemia/lymphoma virus negative Sézary leukemia, and their distinction using anti-Tac: monoclonal antibody identifying the human receptor for T cell growth factor, J. Clin. Invest. 73:1711 (1984).Google Scholar
  29. 29.
    T. Uchiyama, T. Hori, M. Tsudo, Y. Wano, H. Umadome, S. Tamori, J. Yodoi, M. Maeda, H. Sawami, and H. Uchino, Interleukin-2 receptor (Tac antigen) expressed on adult T cell leukemia cells, J. Clin. Invest. 76:446 (1985).Google Scholar
  30. 30.
    R. Schwarting, J. Gerdes, and H. Stein, Expression of interleukin-2 receptor on Hodgkin’s and non-Hodgkin’s lymphoma and macrophages, J. Clin. Pathol. 38:1196 (1985).Google Scholar
  31. 31.
    S.J. Korsmeyer, W.C. Greene, J. Cossman, S.M. Hsu, J.P. Jensen, L.M. Neckers, S.L. Marshall, A. Bakhshi, J.M. Depper, W.J. Leonard, E.S. Jaffe, and T.A. Waldmann, Rearrangement and expression of immunoglobulin genes and expression of Tac antigen in hairy cell leukemia, Proc. Natl. Acad. Sci. USA 80:4522 (1983).Google Scholar
  32. 32.
    T. Diamantstein and H. Osawa, The interleukin-2 receptor, its physiology and a new approach to a selective immunosuppressive therapy by anti-interleukin-2 receptor monoclonal antibodies, Immunol. Rev. 92:5 (1986).Google Scholar
  33. 33.
    T. Uchiyama, J. Yodoi, K. Sagawa, K. Takatsuki, and H. Uchino, Adult T-cell leukemia: clinical and hematologic features of 16 cases, Blood 50:481 (1977)Google Scholar
  34. 34.
    B.J. Poiesz, F.W. Ruscetti, A.F. Gazdar, P.A. Bunn, J.D. Minna, and R.C. Gallo, Detection and isolation of type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphoma, Proc. Natl. Acad. Sci. USA 77:7415 (1980).Google Scholar
  35. 35.
    M. Seiki, S. Hattori, Y. Hirayama, and M. Yoshida, Human adult T-ce1lleukemia virus: complete nucleotide sequence of the provirus genome integrated in leukemia cell DNA, Proc. Natl. Acad. Sci. USA 80:3618 (1983).Google Scholar
  36. 36.
    J.G. Sodroski, C.A. Rosen, and W.A. Haseltine, Trans-acting transcriptional activation of the long terminal repeat of human T lymphotropic viruses in infected cells, Science 225:381 (1984).Google Scholar
  37. 37.
    T.A. Waldmann, C.K. Goldman, K.F. Bongiovanni, S.O. Sharrow, M.P. Davey, K.B. Cease, S.J. Greenberg, and D. Longo, Therapy of patients with human T cell lymphotrophic virus I-induced adult T-cell leukemia with anti-Tac, a monoclonal antibody to the receptor for interleukin-2, Blood 72:1805 (1988).Google Scholar
  38. 38.
    T.A. Waldmann, Monoclonal antibodies in diagnosis and therapy, Science 252:1659 (1991).Google Scholar
  39. 39.
    M. Maeda, N. Arima, Y. Daitoku, M. Kashihara, H. Okamoto, T. Uchiyama, K. Shirono, M. Matsuka, T. Hattori, K. Takatsuki, K. Ikuta, A. Shimuzu, T. Honjo, and J. Yodoi, Evidence for the interleukin-2 dependent expansion of leukemic cells in adult T-cell leukemia, Blood 70:1407 (1987).Google Scholar
  40. 40.
    J.M. Depper, W.J. Leonard, T.A. Waldmann, and W.C. Greene, Blockade of the interleukin-2 receptor by anti-Tac antibody: inhibition of human lymphocyte activation, J. Immunol. 131:690 (1983).Google Scholar
  41. 41.
    R.L. Kirkman, L.V. Barrett, and G.N. Gaulton, Administration of an anti interleukin-2 receptor monoclonal antibody prolongs cardiac allograft survival in mice, J. Exp. Med. 162:358 (1985).Google Scholar
  42. 42.
    M.H. Reed, M.E. Shapiro, T.B. Strom, E.L. Milford, C.B. Carpenter, D.S. Weinberg, K.A. Reimann, N.L. Letvin, T.A. Waldmann, and R.L. Kirkman, Prolongation of primate renal allograft survival by anti-Tac, an anti-human IL-2 receptor monoclonal antibody, Transplantation 47:55 (1989).Google Scholar
  43. 43.
    P.S. Brown, Jr., G.L. Parenteau, F.M. Dirbas, R.J. Garsia, C.K. Goldman, M.A. Bukowski, R.P. Junghans, C. Queen, J. Hakimi, W. Benjamin, R.E. Clark, and T.A. Waldmann, Anti-Tac-H, a humanized antibody to the interleukin-2 receptor prolongs primate cardiac allograft survival, Proc. Natl. Acad. Sci. USA 88:2663 (1991).Google Scholar
  44. 44.
    R.L. Kirkman, M.E. Shapiro, C.B. Carpenter, D.B. McKay, D.L. Milford, E.L. Ramos, N.L. Tilney, T.A. Waldmann, C.E. Zimmerman, and T.B. Strom, A randomized prospective trial of anti-Tac monoclonal antibody in human renal transplantation, Transplantation 51:107 (1991).Google Scholar
  45. 45.
    J. Hwang, D.J. FitzGerald, P. Adhya, and I. Pastan, Functional domains of Pseudomonas exotoxin identified by deletion analysis of the gene expressed in E. coli, Cell 48:129 (1987).Google Scholar
  46. 46.
    R.I. Kreitman, V.K. Chaudhary, T.A. Waldmann, M.C. Willingham, D.I. FitzGerald, and I. Pastan, The recombinant immunotoxin anti-Tac (Fv)-PE40 is cytotoxic toward peripheral blood malignant cells from patients with adult T-cell leukemia, Proc. Natl. Acad. Sci. USA 87:8291 (1990).Google Scholar
  47. 47.
    M.M. Cooper, R.C. Robbins, C.K. Goldman, S. Mirzadeh, C. Stone, O.A. Gansow, R.E. Clark, and T.A. Waldmann, Use of yttrium-90-labeled anti-Tac antibody in primate xenograft transplantation, Transplantation 50:760 (1990).Google Scholar

Copyright information

© Springer Science+Business Media New York 1992

Authors and Affiliations

  • Thomas A. Waldmann
    • 1
  • Carolyn Goldman
    • 1
  • Lois Top
    • 1
  • Angus Grant
    • 1
  • Jack Burton
    • 1
  • Richard Bamford
    • 1
  • Erich Roessler
    • 1
  • Ivan Horak
    • 1
  • Sara Zaknoen
    • 1
  • Claude Kasten-Sportes
    • 1
  • Jeffrey White
    • 1
  • David Nelson
    • 1
  1. 1.Metabolism BranchNational Cancer Institute National Institutes of HealthBethesdaUSA

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