Integrins, γδ T Cells, and Autoimmunity

  • Ethan M. Shevach
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 323)


T lymphocytes can be divided into two major lineages. The majority of peripheral T lymphocytes express the ∝β TCR and recognize antigen in association with MHC class I or class II molecules, while a second minor subpopulation of T lymphocytes expresses the γδ chains (1). The nature of the antigen recognized by this latter population or the nature of the restriction element utilized remain poorly characterized (2). One major subpopulation of γδ cells which express the Vγ1.1Cγ4, Vδ6Cδ TCR (hereafter referred to as Vγ1.1 Vδ6 TCR) has been isolated from newborn thymus and hybridomas which express this TCR spontaneously produce IL-2 (3). It has been postulated that spontaneous cytokine production by these hybridomas is secondary to recognition of an autoantigen, possibly an autologous heat shock protein, expressed on the surface of the thymic hybridomas themselves (4).


Cytokine Production Accessory Molecule Autoreactive Cell Indicator Cell Line Murine Epidermis 
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Copyright information

© Springer Science+Business Media New York 1992

Authors and Affiliations

  • Ethan M. Shevach
    • 1
  1. 1.Laboratory of ImmunologyNational Institute of Allergy and Infectious Diseases, National Institutes of HealthBethesdaUSA

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