Multidrug Resistant Gene 1 Product in Human T Cell Subsets: Role of Protein Kinase C Isoforms and Regulation by Cyclosporin A

  • Sudhir Gupta
  • Takashi Tsuruo
  • Sastry Gollapudi
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 323)


The mdr 1 gene codes for a 170 kd P-glycoprotein (Pgp). The Pgp is a plasma membrane glycoprotein that shares extensive homology with numerous bacterial and eukaryotic transport proteins.1-3 The sequence encoding Pgp reveals a tandemly duplicated molecule of approximately 1280 amino acids. Each half consists of a large hydrophobic domain containing 6 putative membrane spanning ∝-helices and a highly conserved hydrophilic domain with an A TP binding site.4 P-glycoprotein has been implicated to play a major role in acquired multidrug resistance in cancer cells,6,6 in chloroquine-resistant Plasmodium falciparum infection,7,8 and possibly in human immunodeficiency virus 1 resistance to azidothymidine.9


Cystic Fibrosis Transmembrane Conductance Regulator Phorbol Myristate Acetate Multidrug Resistant Gene Cytotoxic Molecule Cystic Fibrosis Gene 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1992

Authors and Affiliations

  • Sudhir Gupta
    • 1
  • Takashi Tsuruo
    • 2
  • Sastry Gollapudi
    • 1
  1. 1.Division of Basic and Clinical ImmunologyUniversity of CaliforniaIrvineUSA
  2. 2.Cancer Chemotherapy CenterJapanese Foundation for Cancer ResearchTokyo 170Japan

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