Dissection of the Hb(64–76) Determinant Reveals That the T Cell Receptor May Have the Capacity to Differentially Signal
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The T cell inducing determinant Hb(64-76) was initially identified in studies examining the processing and presentation of the self antigen hemoglobin1. Murine hemoglobin exists in two allelic forms, Hbbs and Hbbd. Immunization of H-2k mice expressing the Hbbs allele, e.g. CE/J, with purified hemoglobin from Hbbd mice, e.g. CBA/J, resulted in a strong T cell response. This allelic response is entirely directed against a single determinant composed of residues 64-76 of the Hbbdminor chain. Three of the 13 amino acid differences between the s and d allelic forms of hemoglobin are found in this region.
KeywordsCritical Residue Allelic Form Contact Residue Wild Type Peptide Conservative Amino Acid Substitution
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