Leukocyte-Endothelial Cell Adhesion as an Active, Multi-Step Process: A Combinatorial Mechanism for Specificity and Diversity in Leukocyte Targeting

  • Eugene C. Butcher
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 323)


The recruitment of leukocytes from the blood is one of the most dramatic cellular responses to tissue damage and inflammation, and is central to the physiologic trafficking of lymphocytes. Leukocyte extravasation is exquisitely regulated in vivo by mechanisms of selective leukocyte-endothelial cell (EC) recognition. Such selective recognition events help determine the degree and character of local inflammatory reactions by controlling the extravasation of neutrophils, monocytes and other leukocytes; facilitate immune surveillance by directing the recirculation pathways of virgin and memory lymphocytes; and support regional immune responses by targeting lymphocyte effector cells to particular organs and tissues in the body. The interaction of lymphocytes and leukocytes with the vascular endothelium in vivo can display extraordinary specificity in relation to the inflammatory stimulus, the stage of the inflammatory response, and the tissue site or organ involved. Examples include the almost exclusive attachment of eosinophils to venules in allergic reactions, the specific recruitment of monocytes to cerebral vessels in mouse models of cerebral malaria, and the tissue-selective interaction of lymphocyte subsets with high endothelial venules (HEV) in organized lymphoid tissues.


Cerebral Malaria Adhesion Receptor Peripheral Lymph Node High Endothelial Venule Homing Receptor 
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  1. M. Amin Arnaout—Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02114Google Scholar
  2. Eugene C. Butcher—Department of Pathology, Stanford University School of Medicine, Stanford, California 94305-5324Google Scholar
  3. Kenneth Dorshkind—Division of Biomedical Sciences, University of California, Riverside, California 92521-0121Google Scholar
  4. Brian D. Evavold—Department of Pathology, Washington University School of Medicine, St. Louis, Missouri 6311 0Google Scholar
  5. Sudhir Gupta—Department of Medicine, University of California, Irvine, California 92717Google Scholar
  6. Martin E. Hemler—Divison of Tumor Virology, Dana-Farber Cancer Institute, Boston, Massachusetts 02115Google Scholar
  7. Marilyn Kehry—Department of Molecular Biology, Boehringer Ingelheim Pharmaceuticals, Ridgefield, Connecticut 06877Google Scholar
  8. Richard D. Klausner—Cell Biology and Metabolism Branch, NICHD, National Institutes of Health, Bethesda, Maryland 20892Google Scholar
  9. Ada M. Kruisbeek—Division of Immunology, Netherlands Cancer Institute, Amsterdam, The NetherlandsGoogle Scholar
  10. Jeffrey A. Ledbetter—Bristol-Myers Squibb Pharmaceutical Research Institute, Seattle, Washington 98121Google Scholar
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  14. Linda S. Park—Department of Biochemistry, Immunex Research and Development Corporation, Seattle, Washington 98101Google Scholar
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  16. David H. Raulet—Department of Molecular and Cell Biology, University of California, Berkeley, California 94720Google Scholar
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  23. Thomas J. Waldschmidt—Department of Pathology, University of Iowa, Iowa City, Iowa 52242Google Scholar

Copyright information

© Springer Science+Business Media New York 1992

Authors and Affiliations

  • Eugene C. Butcher
    • 1
    • 2
  1. 1.Laboratory of Immunology and Vascular Biology, Department of PathologyStanford University Medical CenterStanfordUSA
  2. 2.Center for Molecular Biology in MedicineVeterans Administration Medical CenterPalo AltoUSA

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