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On the Regulation of β2 Integrins

  • M. Amin Arnaout
  • Masahiro Michishita
  • Chander P. Sharma
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 323)

Abstract

β2 integrins (Leu-CAMs, CD11/CD18) are three heterodimeric surface membrane glycoprotein receptors which mediate a large number of divalentcation- dependent cell-cell and cell-matrix adhesion functions in leukocytes.1 Each heterodimer (Figure 1) consists of a distinct ex subunit (CD11a, CD11b or CD11c) noncovalently associated with a single β subunit (CD18). CD11a/CD18 is expressed on all leukocytes. CD11b and CD11c expression is restricted to myelomonocytic cells and NK cells.

Keywords

Phorbol Ester Cytoplasmic Tail Leukocyte Adhesion Molecule Fibronectin Receptor Amino Acid Segment 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1992

Authors and Affiliations

  • M. Amin Arnaout
    • 1
  • Masahiro Michishita
    • 1
  • Chander P. Sharma
    • 1
  1. 1.Leukocyte Biology and Inflammation Program Renal Unit and Department of MedicineMassachusetts General Hospital and Harvard Medical SchoolBostonUSA

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