Analyses of VLA-4 Structure and Function

  • Paul D. Kassner
  • Joaquin Teixido
  • Bosco M. C. Chan
  • Christina M. Parker
  • Martin E. Hemler
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 323)


The integrin VLA-4 mediates the adhesion of lymphocytes, monocytes, eosinophils and some melanoma cells to VCAM-1 on the surface of activated endothelial cells.1-7 Because the VLA- 4/VCAM-1 pathway plays a prominent role in the migration and localization of these various cell types, it is a potential target of therapeutic intervention that has relevance to inflammation, atherosclerosis,8 allergy and asthma,9,10 and possibly also tumor cell metastasis11 and arthritis.12


K562 Cell Cytoplasmic Domain Cytoplasmic Tail Primary Amino Acid Sequence Human Umbilical Vascular Endothelial Cell 
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Copyright information

© Springer Science+Business Media New York 1992

Authors and Affiliations

  • Paul D. Kassner
    • 1
  • Joaquin Teixido
    • 1
  • Bosco M. C. Chan
    • 1
  • Christina M. Parker
    • 2
  • Martin E. Hemler
    • 1
  1. 1.Division of Tumor VirologyDana-Farber Cancer Institute, Harvard Medical SchoolBostonUSA
  2. 2.Division of Immunochemistry, Department of Rheumatology and ImmunologyDana-Farber Cancer Institute, Harvard Medical SchoolBostonUSA

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