The T Cell Antigen Receptor Tyrosine Kinase Pathway

  • Lawrence E. Samelson
  • Mark Egerton
  • Pamela M. Thomas
  • Ronald L. Wange
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 323)


It is now well accepted that T cell antigen receptor (TCR) engagement induces a cascade of protein phosphorylation with activation of both tyrosine and serine/threonine kinases. The most proximal events in this cascade appear to be the tyrosine phosphorylation of multiple intracellular proteins. This paper summarizes new data from our laboratory and places it in the context of observations made over the past several years. The initial problems that we and others have focused on are the identification and characterization of the kinases, phosphatases, and substrates that make up the elements of this pathway. With this information in hand, one can begin to understand the mechanism of signal transduction at a molecular level.


Tyrosine Phosphorylation Cell Antigen Receptor Induce Tyrosine Phosphorylation Phenylarsine Oxide Tyrosine Phosphatase Inhibitor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1992

Authors and Affiliations

  • Lawrence E. Samelson
    • 1
  • Mark Egerton
    • 1
  • Pamela M. Thomas
    • 1
  • Ronald L. Wange
    • 1
  1. 1.Cell Biology and Metabolism BranchNational Institute of Child Health and Human Development, National Institutes of HealthBethesdaUSA

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