The Low Affinity IgE Fc Receptor (CD23) Participates in B Cell Activation

  • Thomas J. Waldschmidt
  • Lorraine T. Tygrett
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 323)


The low affinity IgE Fc receptor (FcɛRII or CD23) is expressed on all mature B lymphocytes (reviewed in 1 and 2). The FcʵRII is a 45 to 49 KD glycoprotein, and is categorized as a class II transmembrane molecule on account of its inverted membrane orientation. In addition to the transmembrane form of the receptor, a soluble form is readily released from B cells, a result of cleavage by a cell surface protease. cDNA cloning has revealed that the FceRII is a member of the hepatic lectin family, a somewhat unusual finding since all other characterized Fc receptors are known to be members of the immunoglobulin (Ig) gene superfamily.


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  1. 1.
    D.H. Conrad, FCεRII/CD23: The Low Affinity Receptor for IgE, Ann. Rev. Immunol. 8:623 (1990).Google Scholar
  2. 2.
    G. Delespesse, U. Suter, D. Mossalayi, B. Bettler, M. Sarfati, H. Hofstetter, E. Kilcherr, P. Debre, and A. Dalloul, Expression, Structure, and Function of the CD23 Antigen, Adv. Immunol. 49:149 (1991).Google Scholar
  3. 3.
    E. Sherr, E. Macy, H. Kimata, M. Gilly, and A. Saxon, Binding the Low Affinity FCER on B Cells Suppresses Ongoing Human IgE Synthesis, J. Immunol. 142:481 (1989).Google Scholar
  4. 4.
    H. Luo, H. Hofstetter, J. Banchereau, and G. Delesspesse, Cross-linking of CD23 Antigen by its Natural Ligand (IgE) or by Anti-CD23 Antibody Prevents B Lymphocyte Proliferation and Differentiation, J. Immunol. 146:2122 (1991).Google Scholar
  5. 5.
    M.R. Kehry and L.C. Yamashita, Low-affinity IgE Receptor (CD23) Function on Mouse B Cells: Role in IgE-dependent Antigen Focusing, Proc. Natl. Acad. Sci. U.S.A. 86:7556 (1989).Google Scholar
  6. 6.
    U. Pirron, T. Schlunch, J.C. Prinz, and E.P. Rieber, IgE-dependent Antigen Focusing by Human B Lymphocytes is Mediated by the Low-affinity Receptor for IgE, Eur. J. Immunol. 20:1547 (1990).Google Scholar
  7. 7.
    N.R. StC. Sinclair, Immunoregulation by Antibody and Antigen-antibody Complexes, Trans. Proc. 10:2 (1978).Google Scholar
  8. 8.
    V.T. Oi, P.P. Jones, J.W. Goding, L.A. Herzenberg, and L.A. Herzenberg, Properties of Monoclonal Antibodies to Mouse Ig Allotypes, H-2, and Ia Antigens, Curr. Top. Microbiol. Immunol. 81:115 (1978).Google Scholar
  9. 9.
    J.L. Dangl and L.A. Herzenberg, Selection of Hybridomas and Hybridoma Variants Using the Fluorescence Activated Cell Sorter, J. Immunol. Meth. 52:1 (1982).Google Scholar
  10. 10.
    D.K. Goroff, A.L. Stall, J.J. Mond, and F.D. Finkelman, In Vitro and In Vivo B Lymphocyte-Activating Properties of Monoclonal Anti-δ Antibodies I. Determinants of B Lymphocyte-Activating Properties, J. Immunol. 136:2382 (1986).Google Scholar
  11. 11.
    H. Seyschab, R. Friedl, D. Schindler, H. Hoehn, P.S. Rabinovitch, and U. Chen, The Effects of Bacterial Lipopolysaccharide, Anti-receptor Antibodies and Recombinant Interferon on Mouse B Cell Cycle Progression Using 5-bromo-2’deoxyuridine/Hoechst 33258 Dye Flow Cytometry, Eur. J. Immunol. 19:1605 (1989).Google Scholar
  12. 12.
    M. Rao, W.T. Lee, and D.H. Conrad, Characterization of a Monoclonal Antibody Directed Against the Murine B Lymphocyte Receptor for IgE, J. Imrnunol. 138:1845 (1987).Google Scholar
  13. 13.
    W.T. Lee and D.H. Conrad, The Murine Lymphocyte Receptor for IgE II. Characterization of the Multivalent Nature of the B Lymphocyte Receptor for IgE, J. Exp. Med. 159:1790 (1984).Google Scholar
  14. 14.
    K. Sugie, T. Kawakami, Y. Maeda, T. Kawabe, A. Uchida, and J. Yodoi, Fyn Tyrosine Kinase Associated with FCERII/CD23: Possible Multiple Roles in Lymphocyte Activation, Proc. Natl. Acad. Sci. U.S.A. 88:9132 (1991).Google Scholar

Copyright information

© Springer Science+Business Media New York 1992

Authors and Affiliations

  • Thomas J. Waldschmidt
    • 1
  • Lorraine T. Tygrett
    • 1
  1. 1.Department of PathologyUniversity of Iowa, College of MedicineIowa CityUSA

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