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The Low Affinity IgE Fc Receptor (CD23) Participates in B Cell Activation

  • Thomas J. Waldschmidt
  • Lorraine T. Tygrett
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 323)

Abstract

The low affinity IgE Fc receptor (FcɛRII or CD23) is expressed on all mature B lymphocytes (reviewed in 1 and 2). The FcʵRII is a 45 to 49 KD glycoprotein, and is categorized as a class II transmembrane molecule on account of its inverted membrane orientation. In addition to the transmembrane form of the receptor, a soluble form is readily released from B cells, a result of cleavage by a cell surface protease. cDNA cloning has revealed that the FceRII is a member of the hepatic lectin family, a somewhat unusual finding since all other characterized Fc receptors are known to be members of the immunoglobulin (Ig) gene superfamily.

Keywords

Acridine Orange Parent Protein Stimulatory Capacity Switch Variant Discontinuous Percoll Gradient 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1992

Authors and Affiliations

  • Thomas J. Waldschmidt
    • 1
  • Lorraine T. Tygrett
    • 1
  1. 1.Department of PathologyUniversity of Iowa, College of MedicineIowa CityUSA

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