Role of Contact and Soluble Factors in the Growth and Differentiation of B Cells by Helper T Cells

  • Randolph J. Noelle
  • Lisa Marshall
  • Meenakshi Roy
  • David M. Shepherd
  • Ivan Stamenkovic
  • Jeffrey A. Ledbetter
  • Alejandro Aruffo
  • H. Perry Fell
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 323)


Antigen-specific, class II-restricted interactions have been repeatedly shown to be essential in the initiation of humoral immunity. In addition to TCR, and CD4, other Th molecules, like CD28, ICAM-I, LFA-I and B7 subserve co-stimulatory functions (Fig. I).


Mature Transcript Cell Cycle Entry Purify Plasma Membrane Cognate Interaction CD40 Binding Protein 
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Copyright information

© Springer Science+Business Media New York 1992

Authors and Affiliations

  • Randolph J. Noelle
    • 1
  • Lisa Marshall
    • 1
  • Meenakshi Roy
    • 1
  • David M. Shepherd
    • 1
  • Ivan Stamenkovic
    • 2
  • Jeffrey A. Ledbetter
    • 3
  • Alejandro Aruffo
    • 3
  • H. Perry Fell
    • 3
  1. 1.Department of MicrobiologyDartmouth Medical SchoolLebanon
  2. 2.Department of Pathology, Massachusetts General HospitalHarvard Medical SchoolBostonUSA
  3. 3.Bristol-Myers Squibb Pharmaceutical Research InstituteSeattleUSA

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