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Role of Contact and Soluble Factors in the Growth and Differentiation of B Cells by Helper T Cells

  • Randolph J. Noelle
  • Lisa Marshall
  • Meenakshi Roy
  • David M. Shepherd
  • Ivan Stamenkovic
  • Jeffrey A. Ledbetter
  • Alejandro Aruffo
  • H. Perry Fell
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 323)

Abstract

Antigen-specific, class II-restricted interactions have been repeatedly shown to be essential in the initiation of humoral immunity. In addition to TCR, and CD4, other Th molecules, like CD28, ICAM-I, LFA-I and B7 subserve co-stimulatory functions (Fig. I).

Keywords

Mature Transcript Cell Cycle Entry Purify Plasma Membrane Cognate Interaction CD40 Binding Protein 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1992

Authors and Affiliations

  • Randolph J. Noelle
    • 1
  • Lisa Marshall
    • 1
  • Meenakshi Roy
    • 1
  • David M. Shepherd
    • 1
  • Ivan Stamenkovic
    • 2
  • Jeffrey A. Ledbetter
    • 3
  • Alejandro Aruffo
    • 3
  • H. Perry Fell
    • 3
  1. 1.Department of MicrobiologyDartmouth Medical SchoolLebanon
  2. 2.Department of Pathology, Massachusetts General HospitalHarvard Medical SchoolBostonUSA
  3. 3.Bristol-Myers Squibb Pharmaceutical Research InstituteSeattleUSA

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