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The Role of IL-7 and Its Receptor in B-Cell Ontogeny

  • Linda S. Park
  • Philip J. Morrissey
  • Barry Davison
  • Kenneth Grabstein
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 323)

Abstract

Interleukin-7 is a molecule that was originally identified on the basis of its ability to stimulate growth of murine pre-B cells (1). It appears to be principally a growth factor, not a differentiation factor, and has no effects on mature B cells. How early IL-7 acts in the pathway of B-lymphopoiesis has not been clearly defined; however, it is clear that other factors or signals are required at the very earliest stages of B-lymphopoiesis due to the necessity for contact with a stromal layer. In order to better understand the role of IL-7 in the context of the other factors which may influence B-lymphopoiesis, we have studied the effect of altering in vivo levels of IL-7 in mice. This has been done in three ways: first, by relatively short term administration of IL-7; second, through the generation of IL-7 transgenic mice which result in constitutive overexpression of IL-7; and third, through administration to mice of an anti-IL-7 antibody to remove the in vivo effects of IL-7. Although IL-7 has known effects on a number of cell lineages, the data presented here will concentrate primarily on what happens to the B-cell compartment.

Keywords

Stromal Layer Enlarge Mesenteric Lymph Node Stromal Cell Layer Heat Stable Antigen Agar Bone Marrow 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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    A.E. Namen, A.E. Schmierer, C.J. March, R.W. Overell, L.S. Park, D.L. Urdal, and D.Y. Mochizuki, B cell precursor growth-promoting activity: purification and characterization of a growth factor active on lymphocyte precursors, J. Exp. Med. 167:988 (1988).Google Scholar
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Copyright information

© Springer Science+Business Media New York 1992

Authors and Affiliations

  • Linda S. Park
    • 1
  • Philip J. Morrissey
    • 2
  • Barry Davison
    • 3
  • Kenneth Grabstein
    • 2
  1. 1.Department of BiochemistryImmunex Research and Development CorporationSeattleUSA
  2. 2.Department of ImmunologyImmunex Research and Development CorporationSeattleUSA
  3. 3.Department of TransgenicsImmunex Research and Development CorporationSeattleUSA

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