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Differential Involvement of Protein Tyrosine Kinases p56lck and p59fyn in T Cell Development

  • Nicolai S. C. van Oers
  • Alex M. Garvin
  • Michael P. Cooke
  • Craig B. Davis
  • D. R. Littman
  • Roger M. Perlmutter
  • Hung-Sia Teh
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 323)

Abstract

Mature CD4+ and CD8+ T cells recognize and respond to processed antigens associated with major histocompatibility complex-encoded molecules (MHC). It is during thymic development that selection processes act on immature CD4+CD8+ thymocytes to ensure the fonnation of a repertoire of functional T cells1,2. Thus, immature T cells expressing an ∝β TCR with specificity for self-peptides plus MHC class I or class II molecules are positively selected, differentiating into CD8+ or CD4+ T cells, respectively3,4,5,6. Immature thymocytes lacking or expressing a non-selectable TCR undergo programmed cell death1. Additionally, those CD4+CD8+ T cells expressing an autospecific TCR may undergo programmed cell death 7,8 (negative selection). The CD4 and CD8 molecules are thought to actively participate in these T cell repertoire selection events through their coreceptor functions9. In a coreceptor model, the TCR and appropriate coreceptor molecule recognize and interact with the same MHC molecule, with CD4 or CD8 potentiating TCR-derived intracellular signals10,1l.12. Recent reports have demonstrated that mutations affecting CD8/class I MHC interactions disrupt both positive and negative selection in the thymus13,14.

Keywords

Transgenic Mouse Negative Selection Protein Tyrosine Kinase Double Transgenic Mouse Thymocyte Development 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1992

Authors and Affiliations

  • Nicolai S. C. van Oers
    • 1
  • Alex M. Garvin
    • 2
  • Michael P. Cooke
    • 3
  • Craig B. Davis
    • 4
  • D. R. Littman
    • 4
  • Roger M. Perlmutter
    • 3
  • Hung-Sia Teh
    • 1
  1. 1.Department of MicrobiologyUniversity of British ColumbiaVancouverCanada
  2. 2.CIMLMarseille, Cedex 9France
  3. 3.Departments of Immunology, Biochemistry, and Medicine (Medical Genetics), and the Howard Hughes Medical InstituteUniversity of WashingtonSeattleUSA
  4. 4.Howard Hughes Medical Institute, Department of Microbiology and ImmunologyUniversity of California, San FranciscoSan FranciscoUSA

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