Generation of Mutant Mice Lacking Surface Expression of CD4 or CD8 Gene Targeting

  • Tak W. Mak
  • Amin Rahemtulla
  • Marco Schilham
  • Dow Rhoon Koh
  • Wai Ping Fung-Leung
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 323)


With the use of homologous recombination in embryonic stem cells, two new strains of mice lacking surface CD4 or CDS expression have been generated. It is hoped that they will be useful mouse strains for the study of autoimmune diseases, tissue transplantation rejections and tumour rejections.


Major Histocompatibility Complex Homologous Recombination Experimental Autoimmune Encephalomyelitis Major Histocompatibility Complex Class Tumour Rejection 
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Copyright information

© Springer Science+Business Media New York 1992

Authors and Affiliations

  • Tak W. Mak
    • 1
  • Amin Rahemtulla
    • 1
  • Marco Schilham
    • 1
  • Dow Rhoon Koh
    • 1
  • Wai Ping Fung-Leung
    • 1
  1. 1.The Ontario Cancer Institute Departments of Medical Biophysics and ImmunologyUniversity of TorontoTorontoCanada

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