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T Cell Receptor Structure and Function: Analysis by Expression of Portions of Isolated Subunits

  • Isaac Engel
  • Francois Letourneur
  • John T. B. Houston
  • Tom H. M. Ottenhoff
  • Richard D. Klausner
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 323)

Abstract

The T cell antigen receptor (TCR) is a multi-component cell surface complex composed of the products of at least six genes (1,2). Specific recognition of antigen/MHC is mediated by two chains of the TCR complex (generally ∝ and β) that are expressed as disulfide linked heterodimers and display a high degree of clonotypic diversity. Associated with this specialized heterodimer are the invariant dimers CD3 ε-δ and CD3 ε-γ and a disulfide-linked dimer formed by members of the ζ gene family (typically a ζ-ζ homodimer). The invariant chains of the TCR have been shown to be necessary for efficient assembly and transport of the receptor to the cell surface (3), and are also thought to be essential for signal transduction.

Keywords

Cytoplasmic Tail Invariant Chain Cell Antigen Receptor Heterodimer Formation Chimeric Construct 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1992

Authors and Affiliations

  • Isaac Engel
    • 1
  • Francois Letourneur
    • 1
  • John T. B. Houston
    • 1
  • Tom H. M. Ottenhoff
    • 1
  • Richard D. Klausner
    • 1
  1. 1.Cell Biology and Metabolism BranchNational Institute of Child Health and Human Development, National Institutes of HealthBethesdaUSA

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