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Evaluation of Response of Hepatocytes(in Vivo) to Thermal Neutron Irradiation by Micronucleus Assay

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Progress in Neutron Capture Therapy for Cancer

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Abstract

In order to apply neutron capture therapy to malignant liver tumors, it is necessary to know the effects of thermal neutron irradiation on the normal liver precisely. In this study, we have investigated the response of the hepatocytes in vivo to thermal neutron irradiation by micronucleus assay1,2.

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References

  1. I. Cliet, E. Fournier, C. Melcion, and A. Cordier, In vivo micronucleus test using mouse hepatocytes, Mutation Research, 216:321(1989).

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  2. K. Ono, Y. Nagata, K. Akuta, M. Abe, K. Ando, and S. Koike, Micronucleus frequency in hepatocytes following X-ray and fast neutron irradiation -An analysis by linear quadratic model-, Radiation Research, 123:345(1990).

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  3. T. Kobayashi and K. Kanda, Microanalysis system of ppm-order 10B concentrations in tissue for neutron capture therapy by prompt gamma-ray spectrometry, Nuclear Instruments and Methods, 204:525(1983).

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  4. Y. Ujeno, Physical modification of thermal neutron-induced biological effects, in: Modification of Radiosensitivity in Cancer Treatment, T. Sugahara ed., Academic Press, Tokyo (1984).

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Author information

Authors and Affiliations

  1. Research Reactor Institute, Kyoto University, Kumatori-cho,Sennan-gun, Osaka, 590-04, Japan

    Keizo Akuta, Tooru Kobayashi, Mitsuhiko Akaboshi & Yowri Ujeno

  2. Dept. of Radiology, Faculty of Medicine, Kyoto University,Sakyo-ku, Kyoto, 606, Japan

    Koji Ono & Mitsuyuki Abe

Authors
  1. Keizo Akuta
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  2. Koji Ono
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  3. Tooru Kobayashi
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  4. Mitsuhiko Akaboshi
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  5. Yowri Ujeno
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  6. Mitsuyuki Abe
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Editor information

Editors and Affiliations

  1. Australian Nuclear Science and Technology Organisation, Menai, New South Wales, Australia

    Barry J. Allen  & Baiba V. Harrington  & 

  2. University of Sydney, Sydney, New South Wales, Australia

    Douglas E. Moore

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© 1992 Springer Science+Business Media New York

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Akuta, K., Ono, K., Kobayashi, T., Akaboshi, M., Ujeno, Y., Abe, M. (1992). Evaluation of Response of Hepatocytes(in Vivo) to Thermal Neutron Irradiation by Micronucleus Assay. In: Allen, B.J., Moore, D.E., Harrington, B.V. (eds) Progress in Neutron Capture Therapy for Cancer. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3384-9_99

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  • DOI: https://doi.org/10.1007/978-1-4615-3384-9_99

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6494-8

  • Online ISBN: 978-1-4615-3384-9

  • eBook Packages: Springer Book Archive

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