Abstract
Gadolinium neutron capture(GNC) therapy as proposed in 1936 by Gordon Locher[1] and recently by others[2,3,4,5,6] takes advantage of its extraordinarily large cross section to thermal neutrons. In GNC reactions, prompt high energy gamma rays, x rays and electrons are released[3]. Because of the photons and electrons, the intracellular presence of gadolinium is not considered critical. This is an advantage over boron-neutron capture therapy where the intracellular presence of boron is required because of the short flight tracks of 2.4 MeV alpha particles. In this study, the radiation effect of GNC reactions was measured using Chinese hamster cells in an attempt to evaluate the contributions of neutrons, gamma rays and electrons on cell inactivation.
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References
Locher G L. Biological effects and therapeutic possibilities of neutrons. Amer J Roentgenol. 36:1,1936.
Martin R F, D’Cunha G, Pardee M and Allen B J. Induction of double-strand breaks following neutron capture by DNA-bound Gd-157. Int J Radia Biol. 54: 205, 1988.
Allen B J, McGregor B J and Martin R F. Neutron capture therapy with Gd-157. Strahlenther Onkol. 165: 156,1989.
Brugger R M and Shih J A. Evaluation of gadolinium-157 as a neutron capture therapy agent. Strahlenther Onkol. 165: 153,1989.
Ryabukhin Y S. Integrated approach in the planning of neutron capture therapy. Strahlenther Onkol. 165:158, 1989.
Akine Y, Tokita N, Matsumoto T, Oyama H, Egawa S, Aizawa O. Radiation effect of gadolinium-neutron capture reactions on the survival of Chinese hamster cells. Strahlenther Onkol. 166: 831, 1990.
Matsumoto T. Aizawa O, Nozaki T and Sato T. Present status of the medical irradiation facility at the Musashi reactor. Pigment Cell Res 2: 240, 1989.
Conde H, Crawford J F, Dahl B, Grussel E, Larsson B, Petterson C B, Reist H, Sjostrand N G, Sornsuntisook O and Thuresson L. The production by 72 MeV protons of keV neutrons for B-10 neutron capture therapy. Strahlenther Onkol. 165: 340,1989.
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© 1992 Springer Science+Business Media New York
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Akine, Y., Tokita, N., Matsumoto, T., Oyama, H., Aizawa, O. (1992). Gadolinium-Neutron Capture Reactions: A Radiobiological Assay. In: Allen, B.J., Moore, D.E., Harrington, B.V. (eds) Progress in Neutron Capture Therapy for Cancer. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3384-9_79
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DOI: https://doi.org/10.1007/978-1-4615-3384-9_79
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