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Further in Vitro Radiobiological Analysis on 10B-BPA BNCT of Malignant Melanoma: Correlation of Determined 10B-Content and Cell Killing Effect

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Progress in Neutron Capture Therapy for Cancer

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Abstract

The successful application of boron neutron capture therapy (BNCT) for melanoma depends on the following points, (1) high accumulation of 10B in target melanoma cells (approcimately 20 ppm) and (2) high tumor/normal tissue10B ratio, theoretically greater than 5.

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References

  1. Mishima Y, Honda C, Ichihashi M, et al: Treatment of malignant manoma by single thermal neutron capture therapy with melanoma-seeking 10B- compound. Lancet 2:388, 1989.

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  2. Hori Y, Nakamura K, Matsuoka M et al: Determination of 10B in biological samples by ICP-AES and IPC-MS. The 4th Japan-Australia International Workshop on Thermal Neutron Capture Therapy for Malignant Melanoma, Kobe, Feb. 13–17, 1989.

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  3. Ichihashi M, Sasase A,,iramoto T, et al: RBE of thermal neutron capture therapy using 10B1-paraboronophynelalanine for human and B-16 melanoma cells. Strahlen und Onkologie 165:198, 1989.

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Author information

Authors and Affiliations

  1. Depts. Derm., Special Inst. Cancer Neutron Capture Therapy, Kobe Univ. Sch. Med., Kobe, 650, Japan

    M. Ichihashi, M. Shiono, K. Yamamura, A. Komura & Y. Mishima

  2. Dept. Chem., Fac. Sci., Shinshu Univ., Matsumoto, 390, Japan

    K. Yoshino

  3. Kyoto Univ. Res Reactor Inst., Osaka, 590-04, Japan

    T. Kobayashi & K. Kanda

  4. Natl. Inst. Radiol. Sci., Chiba, 280, Japan

    H. Fukuda

  5. Shiseido Res. Cent., Yokohama, 223, Japan

    Y. Hori

Authors
  1. M. Ichihashi
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  2. M. Shiono
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  3. K. Yamamura
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  4. A. Komura
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  5. Y. Mishima
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  6. K. Yoshino
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  7. T. Kobayashi
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  8. K. Kanda
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  9. H. Fukuda
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  10. Y. Hori
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Editor information

Editors and Affiliations

  1. Australian Nuclear Science and Technology Organisation, Menai, New South Wales, Australia

    Barry J. Allen  & Baiba V. Harrington  & 

  2. University of Sydney, Sydney, New South Wales, Australia

    Douglas E. Moore

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© 1992 Springer Science+Business Media New York

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Ichihashi, M. et al. (1992). Further in Vitro Radiobiological Analysis on 10B-BPA BNCT of Malignant Melanoma: Correlation of Determined 10B-Content and Cell Killing Effect. In: Allen, B.J., Moore, D.E., Harrington, B.V. (eds) Progress in Neutron Capture Therapy for Cancer. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3384-9_77

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  • DOI: https://doi.org/10.1007/978-1-4615-3384-9_77

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6494-8

  • Online ISBN: 978-1-4615-3384-9

  • eBook Packages: Springer Book Archive

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