Abstract
The 10B-compounds as the carriers of 10B atoms are one of the keys to make BNCT succeed. Recently, we synthesized some derivatives of nucleic acids containing 10B. The present study deals with the enhanced killing of HeLa S3 cells containing these compounds in vitro by irradiation in the thermal neutron beam of the Kyoto University Reactor (KUR). The enhancement was measured with the changes in 4 radiobiological parameters.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Ujeno, Y., Akaboshi, M., Maki, H. and Kawai, K., 1990, Mathematical analysis of the survival of HeLa S3 cells following neutron capture radiation: calculation of RBE by a linear-quadratic model, Annu.Rep.Res.Reactor Inst., Kyoto Univ., 23:91–96.
Fertil, B., Dertinger, H., Courdi,A. and Malaise, E.P.,1984, Mean inactivation doses: a useful concept for intercomparison of human cell survival curves, Radiat.Res.,99:73–84.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1992 Springer Science+Business Media New York
About this chapter
Cite this chapter
Ujeno, Y., Akaboshi, M., Akuta, K., Maki, T., Kawai, K., Yamamoto, Y. (1992). Enhancement of Thermal Neutron Induced Killing Effect on Hela Cells Containing Boron-10 Nucleic Acid Derivatives. In: Allen, B.J., Moore, D.E., Harrington, B.V. (eds) Progress in Neutron Capture Therapy for Cancer. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3384-9_76
Download citation
DOI: https://doi.org/10.1007/978-1-4615-3384-9_76
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-6494-8
Online ISBN: 978-1-4615-3384-9
eBook Packages: Springer Book Archive