Abstract
An essential aspect of boron neutron capture therapy (BNCT) research is the synthesis of boronated compounds that demonstrate selective uptake into tumor cells. A corollary of this goal is the development of analytical methods for evaluating the uptake, localization, and retention of these compounds in biological test systems (cell culture and animal models). Quantification of boron at the level of individual cells allows direct comparison of drug uptake across various cell lines or tissue compartments. This ability would give direct evidence of selective drug uptake by targeted malignancies.
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© 1992 Springer Science+Business Media New York
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Zha, X., Bennett, B.D., Ausserer, W.A., Morrison, G.H. (1992). Intracellular Boron Uptake and Distribution of BSH and BPA Determined Using Ion Microscopy. In: Allen, B.J., Moore, D.E., Harrington, B.V. (eds) Progress in Neutron Capture Therapy for Cancer. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3384-9_72
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DOI: https://doi.org/10.1007/978-1-4615-3384-9_72
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