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Boron-10 Prompt Gamma Analysis Using a Diffracted Neutron Beam

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Progress in Neutron Capture Therapy for Cancer

Abstract

A prompt gamma neutron activation analysis (PGNAA) facility has been built at the 5 MW MITR-II Research Reactor to support our ongoing boron neutron capture therapy (NCT) program. This facility is used to determine the concentration of B-10 in NCT relevant samples such as blood and urine. The B-10 concentration is needed to determine the radiation doses that tumor and healthy brain receive during neutron irradiation of a patient (1). Assaying for B-10 by PGNAA has several advantages over conventional chemical methods. It is rapid, accurate, nondestructive (allowing for re-analysis), inexpensive, sensitive (ppm level), generally independent of the chemical or physical matrix of the B-10, and does not require chemical manipulations of the sample.

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References

  1. H. Madoc-Jones, D. E. Wazer, R.G. Zamenhof, O. K. Harling, J. A. Bernard, “Clinical Considerations for Neutron Capture Therapy of Brain Tumors,” in Proceedings of an International Workshop on Neutron Beam Design. Development. and Performance for Neutron Capture Therapy O. K. Harling, J. A. Bernard. R. G. Zamenhof, eds., Plenum Press, New York. (1990).

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Author information

Authors and Affiliations

  1. Nuclear Reactor Laboratory, Massachusetts Institute of Technology, 138 Albany Street, Cambridge, MA, 02139, USA

    R. Rogus, O. K. Harling, I. Olmez & S. Wirdzek

Authors
  1. R. Rogus
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  2. O. K. Harling
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  3. I. Olmez
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  4. S. Wirdzek
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Editor information

Editors and Affiliations

  1. Australian Nuclear Science and Technology Organisation, Menai, New South Wales, Australia

    Barry J. Allen  & Baiba V. Harrington  & 

  2. University of Sydney, Sydney, New South Wales, Australia

    Douglas E. Moore

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© 1992 Springer Science+Business Media New York

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Rogus, R., Harling, O.K., Olmez, I., Wirdzek, S. (1992). Boron-10 Prompt Gamma Analysis Using a Diffracted Neutron Beam. In: Allen, B.J., Moore, D.E., Harrington, B.V. (eds) Progress in Neutron Capture Therapy for Cancer. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3384-9_65

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  • DOI: https://doi.org/10.1007/978-1-4615-3384-9_65

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6494-8

  • Online ISBN: 978-1-4615-3384-9

  • eBook Packages: Springer Book Archive

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