Continuous Measurement of Boron-10 Concentration in Rabbit Brain Tissue and Blood Using Prompt Gamma-Ray Spectrometry

Nakagawa, Yoshinobu; Kobayashi, Tooru; Ueno, Youri; Hatanaka, Hiroshi; Mukai, Kanji; Matsumoto, Keizo

doi:10.1007/978-1-4615-3384-9_61

Yoshinobu Nakagawa³,
Tooru Kobayashi⁴,
Youri Ueno⁴,
Hiroshi Hatanaka⁵,
Kanji Mukai⁶ &
…
Keizo Matsumoto⁶

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Abstract

One of the important factors which influences the efficacy of boron neutron capture therapy (BNCT) in patients with malignant brain tumour is the boron-10 concentrations in tumours. The boron-10 concentration in normal brain tissue and the tumour/blood concentration ratio are also valuable factors to decide the irradiation time and protect the normal tissue from radiation injury. Therefore, it is valuable to know the boron-10 concentration in the tumour, normal brain tissue and blood just before and during neutron irradiation. In this study we investigated continuously the boron-10 concentrations in the normal brain tissue of living rabbits and blood for 5 – 24 hours after injection of boron-10 compound using prompt gamma-ray spectrometry.

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References

Kobayashi T. and Kanda K. 1983, Microanalysis system of ppm-order ¹⁰B concentration in tissue for neutron capture therapy by prompt gamma-ray spectrometry, Nuclear Instruments and Methods 204:525–531.
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Authors and Affiliations

Dept. of Neurosurgery, National Kagawa Children’s Hospital, Kagawa, 765, Japan
Yoshinobu Nakagawa
Research Reactor Institute, Kyoto University, Osaka, 590-04, Japan
Tooru Kobayashi & Youri Ueno
Dept. of Neurosurgery, Teikyo University, Tokyo, 173, Japan
Hiroshi Hatanaka
Dept. of Neurosurgery, Tokushima University, Tokushima, 770, Japan
Kanji Mukai & Keizo Matsumoto

Authors

Yoshinobu Nakagawa
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Tooru Kobayashi
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Youri Ueno
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Hiroshi Hatanaka
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Kanji Mukai
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Keizo Matsumoto
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Editors and Affiliations

Australian Nuclear Science and Technology Organisation, Menai, New South Wales, Australia
Barry J. Allen & Baiba V. Harrington &
University of Sydney, Sydney, New South Wales, Australia
Douglas E. Moore

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Nakagawa, Y., Kobayashi, T., Ueno, Y., Hatanaka, H., Mukai, K., Matsumoto, K. (1992). Continuous Measurement of Boron-10 Concentration in Rabbit Brain Tissue and Blood Using Prompt Gamma-Ray Spectrometry. In: Allen, B.J., Moore, D.E., Harrington, B.V. (eds) Progress in Neutron Capture Therapy for Cancer. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3384-9_61

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DOI: https://doi.org/10.1007/978-1-4615-3384-9_61
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-6494-8
Online ISBN: 978-1-4615-3384-9
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