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Antibody Targeting of Boron Compounds

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Progress in Neutron Capture Therapy for Cancer

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Abstract

Success of 10BNCT depends on localising sufficient 10B (around 20μg/g of tumour) at the site of the tumour. One approach is to direct boronated monoclonal antibodies to specific tumour antigens. The method is dependent on the requirements that (i) each antibody carries 1000–2000 10B atoms, (ii) the specific immunoreactivity of the antibody is retained, (iii) the boronated antibody is water-soluble and stable under physiological conditions.

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References

  1. H. Hatanaka (ed.), “Boron Neutron Capture Therapy for Tumours”, Nishima, Tokyo (1986).

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Author information

Authors and Affiliations

  1. Departments of Immunology and Pure and Applied Chemistry, University of Strathclyde, Glasgow, Scotland, UK

    V. A. Ferro, J. H. Morris & W. H. Stimson

Authors
  1. V. A. Ferro
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  2. J. H. Morris
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  3. W. H. Stimson
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Editor information

Editors and Affiliations

  1. Australian Nuclear Science and Technology Organisation, Menai, New South Wales, Australia

    Barry J. Allen  & Baiba V. Harrington  & 

  2. University of Sydney, Sydney, New South Wales, Australia

    Douglas E. Moore

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© 1992 Springer Science+Business Media New York

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Ferro, V.A., Morris, J.H., Stimson, W.H. (1992). Antibody Targeting of Boron Compounds. In: Allen, B.J., Moore, D.E., Harrington, B.V. (eds) Progress in Neutron Capture Therapy for Cancer. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3384-9_58

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  • DOI: https://doi.org/10.1007/978-1-4615-3384-9_58

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6494-8

  • Online ISBN: 978-1-4615-3384-9

  • eBook Packages: Springer Book Archive

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