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Complex Formation of Phenylboronic Acid Derivatives with Aldopentoses and Oligosaccharides

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Progress in Neutron Capture Therapy for Cancer

Abstract

p-Boronophenylalanine (p-bpa) has been studied for use in neutron capture therapy for melanoma [1,2,3,4]. The solubility of p-bpa is only 1.6 g/L in water, which is too small for medical uses. It is desirable and necessary to find a method to increase the solubility of p-bpa at the pH value of blood (pH 7.4).

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References

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Author information

Authors and Affiliations

  1. Department of Chemistry, Faculty of Science, Shinshu University Asahi, Matsumoto, 390, Japan

    Y. Kinoshita, K. Yoshino & Y. Mori

  2. Department of Chemistry, Faculty of Science and Engineering Sophia University, Kioi-cho, Chiyoda-ku, Tokyo, 102, Japan

    H. Kakihana

  3. Department of Dermatology, Kobe University School of Medicine Kusunoki-cho, Chuo-ku, Kobe, 650, Japan

    Y. Mishima

Authors
  1. Y. Kinoshita
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  2. K. Yoshino
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  3. Y. Mori
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  4. H. Kakihana
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  5. Y. Mishima
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Editor information

Editors and Affiliations

  1. Australian Nuclear Science and Technology Organisation, Menai, New South Wales, Australia

    Barry J. Allen  & Baiba V. Harrington  & 

  2. University of Sydney, Sydney, New South Wales, Australia

    Douglas E. Moore

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© 1992 Springer Science+Business Media New York

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Kinoshita, Y., Yoshino, K., Mori, Y., Kakihana, H., Mishima, Y. (1992). Complex Formation of Phenylboronic Acid Derivatives with Aldopentoses and Oligosaccharides. In: Allen, B.J., Moore, D.E., Harrington, B.V. (eds) Progress in Neutron Capture Therapy for Cancer. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3384-9_52

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  • DOI: https://doi.org/10.1007/978-1-4615-3384-9_52

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6494-8

  • Online ISBN: 978-1-4615-3384-9

  • eBook Packages: Springer Book Archive

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