Abstract
The first clinical trials of NCT were initiated at Brookhaven in 1951, using the Brookhaven Graphite Research Reactor (BGRR). Subsequently, the Brookhaven Medical Research Reactor (BMRR) was built primarily for clinical applications of NCT, with an improved beam extraction facility providing flexibility for future development of filters/moderators for NCT. This flexibility was exploited to provide an optimized epithermal neutron beam which was recently installed and tested in the east irradiation facility (shutter) of the BMRR.
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Fairchild, R.G., Saraf, S.K., Kalef-Ezra, J., and Laster, B.H. Comparison of measured parameters from a 24 keV and a broad spectrum epithermal neutron beam for neutron capture therapy (NCT): An identification of consequential parameters. Med. Phys. 17, 1045–1052 (1990).
Fairchild, R.G., Bond, V.P., and Woodhead, A., Eds. Clinical Aspects of Neutron Capture Therapy. Basic Sciences Series, Vol. 50, Plenum Press, New York (1989).
Fairchild, R.G., Kalef-Ezra, J., Saraf, S.K., Fiarman, S., Ramsay, E., Wielopolski, L., Laster, B., and Wheeler, F. Installation and testing of an optimized epithermal neutron beam at the Brookhaven Medical Research Reactor. Proc. of Workshop on Neutron Beam Design, Development and Performance for Neutron Capture Therapy. O.K. Harling, JA. Bernard, and R.G. Zamenhof, Eds. Pg. 185–200, Vol. 54 Basic Life Sciences. Plenum Press, New York (1990).
Gavin, P.R., DeHaan, C.E., Kraft, S.L., and Moore, M.P. Dosimetric considerations: Radiation tolerance of the normal canine brain following boron neutron capture therapy. Proc. Radiation Research Meeting, New Orleans, 1990.
DeHaan, C.E., Gavin, P.R., Kraft, S.L., and Leathers, C.W. The effects of boron neutron capture therapy on the normal canine brain: Gross and histological observations. Proc. Rad. Res. Meeting, New Orleans, 1990.
Sen. J. McClure: Letter to Adm. J. Watkins, Aug. 22, 1990.
Gabel, D., Fairchild, R.G., Borner, H.G., and Larsson, B. The relative biological effectiveness in V79 Chinese hamster cells of the neutron capture reactions in boron and nitrogen. Radiat. Res. 98, 307–316 (1984).
Gabel, D., Foster, S., and Fairchild, R.G. The Monte-Carlo simulation of the biological effect of the 10B(n,α)7Li reaction in cells and tissue and its implication for boron neutron capture therapy. Radiat. Res. 111, 14–25 (1987).
Fairchild, R.G., Kahl, S.B., Laster, B.H., Kalef-Ezra, J., and Popenoe, EA. In vitro determination of uptake, retention, distribution, biological efficacy and toxiCity of boronated compounds for neutron capture therapy: A comparison of porphyrine with sulfhydryl boron hydrides. Cancer Res. 50, 4860–4865 (1990).
Fairchild, R.G., Laster, B.H., and Kalef-Ezra, J. RBE of fast and epithermal neutrons at the BMRR epithermal neutron beam. In preparation.
Rydin, RA., Deutsch, O.L., and Murray, B.W. Phys. Med. Biol. 21, 134–138 (1976).
Joel, D.D., Fairchild, R.G., Laissue, JA., Saraf, S.K., Kalef-Ezra, JA., and Slatkin, D.N. Boron Neutron Capture of intracellular rat gliosarcoma. Proc. Nat. Acad. Sci. In press (Dec. 1990).
Gabel, D. Goals of the European Collaboration on BNCT. (This Conference).
Fairchild, R.G., Kalef-Ezra, J., Fiarman, S., and Wheeler, F. Physics aspects of boron neutron capture therapy: Epithermal neutron beam optimization. Proceedings of 1988 International Reactor Physics Conference, Jackson Hole, Wyoming. Sept. 18–21, Vol. II, pp. 423–432 (1988).
Parsons, D.K., Wheeler, F.J., Rushton, B.C., and Nigg, D.W. Neutronic design of the INEL facility for BNCT clinical trials. Proceedings of 1988 International Reactor Physics Conference, Jackson Hole, Wyoming. Sept. 18–21, Vol. II, pp. 433–442 (1988).
Brugger, R.M., and Shih, JA. Personal communication.
Gregoire, V., Keyeux, A., and Wambersie, A. Blood-brain barrier impairment after irradiation: Implication in BNCT. Clinical Aspects of NCT, R. Fairchild, V. Bond and A. Woodhead, Eds. Basic Life Sciences, Vol. 50, pp 299–310. Plenum Press, New York (1989).
Kalef-Ezra, J., Laster, B.H., and Fairchild, R.G. Integrity of the blood brain barrier following fractionated BNCT. In preparation.
Gajewski, J., Ramsay, E.B., Reinstein, L.E., Saraf, S., and Fairchild, R.G. Monte Carlo calculations results for the epithermal neutron beam at the Medical Reactor. (This Conference).
Laster, B.H., Kahl, S.B., Koo, M.-S., and Fairchild, R.G. Biological efficacy of a boronated porphyrin for neutron capture therapy in a murine tumor. Submitted.
Laster, B.H., Kahl, S.B., Popenoe, EA., and Fairchild, R.G. Biological efficacy of boronated low density lipoproteins (LDL) for Neutron Capture Therapy (NCT) as measured in cell culture. Submitted.
Gabel, D., Holstein, H., Larsson, B., Gille, L., Eriksson, C., Sacker, D., Som, P., and Fairchild, R.G. Quantitative Neutron Capture radiography for studying the biodistribution of boron-containing compounds. Cancer Res. 47, 5451–5454 (1987).
Choi, JR., Zamenhof, R.G., Yanch, J.C., Rogus, R., and Harling, O.K. Performance of the currently available epithermal neutron beam at the Massachusetts Institute of Technology Research Reactor (MITRII). This symposium.
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Fairchild, R.G. et al. (1992). An Optimized Epithermal Neutron Beam for Neutron Capture Therapy (NCT) at the Brookhaven Medical Research Reactor (BMRR). In: Allen, B.J., Moore, D.E., Harrington, B.V. (eds) Progress in Neutron Capture Therapy for Cancer. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3384-9_1
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DOI: https://doi.org/10.1007/978-1-4615-3384-9_1
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