Abstract
The caged calcium compound nitr-5 was used to investigate the effects of a rapid increase in intracellular calcium concentration on the L-type calcium current (ICa) of guinea pig ventricular cells. Short term inactivation and longer lasting potentiation were observed.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Gurney AM, Charnet P, Pye JM and Nargeot J (1989) Augmentation of cardiac calcium current by flash photolysis of intracellular caged-Ca2+ molecules. Nature, 341:65–68
Harding SE, O’Gara P, Jones SM, Brown LA, Vescovo G and Poole-Wilson PA (1990) Species dependence of contraction velocity in single isolated cardiac myocytes. Cardioscience, 1:49–54
Isenberg G and Klockner U (1882) Calcium tolerant ventricular myocytes prepared by preincubation in a “KB medium”. Pfluger Arch, 395:6–18
Kaplan JH and Ellis-Davies GCR (1988) Photolabile chelators for the rapid photorelease of divalent cations. Proc Natl Acad Sci USA, 85:6571–6575
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1992 Springer Science+Business Media New York
About this chapter
Cite this chapter
Bates, S.E., Gurney, A.M. (1992). Modulation of L-Type Calcium Current in Mammalian Ventricular Myocytes by Photolysis of Caged Calcium. In: Frank, G.B., Bianchi, C.P., ter Keurs, H.E.D.J. (eds) Excitation-Contraction Coupling in Skeletal, Cardiac, and Smooth Muscle. Advances in Experimental Medicine and Biology, vol 311. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3362-7_46
Download citation
DOI: https://doi.org/10.1007/978-1-4615-3362-7_46
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-6483-2
Online ISBN: 978-1-4615-3362-7
eBook Packages: Springer Book Archive