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Endothelium-Dependent and-Independent Relaxation of Aortas from Copper-Deficient Rats

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Excitation-Contraction Coupling in Skeletal, Cardiac, and Smooth Muscle

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 311))

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Summary

Isolated aortas from copper-deficlent rats exhibited reduced ability to relax in response to acetylcholine, histamine and sodium nitroprusside, which suggests that release of endothelium-derived relaxing factor or its interaction with the contractile mechanism is impaired.

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References

  1. H. A. Hunsacker, M. Morita, and K. G. D. Allen, Marginal copper deficiency in rats. Aortal morphology of elastin and cholesterol values in first-generation adult males, Atherosclerosis 51:1–19 (1984).

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Author information

Authors and Affiliations

  1. USDA, ARS, Human Nutrition Research Center Grand Forks, North Dakota, 58202, USA

    Jack T. Saari

Authors
  1. Jack T. Saari
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Editor information

Editors and Affiliations

  1. University of Alberta, Edmonton, Alberta, Canada

    George B. Frank

  2. Thomas Jefferson University, Philadelphia, Pennsylvania, USA

    C. Paul Bianchi

  3. University of Calgary, Calgary, Alberta, Canada

    Henk E. D. J. ter Keurs

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© 1992 Springer Science+Business Media New York

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Saari, J.T. (1992). Endothelium-Dependent and-Independent Relaxation of Aortas from Copper-Deficient Rats. In: Frank, G.B., Bianchi, C.P., ter Keurs, H.E.D.J. (eds) Excitation-Contraction Coupling in Skeletal, Cardiac, and Smooth Muscle. Advances in Experimental Medicine and Biology, vol 311. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3362-7_45

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  • DOI: https://doi.org/10.1007/978-1-4615-3362-7_45

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6483-2

  • Online ISBN: 978-1-4615-3362-7

  • eBook Packages: Springer Book Archive

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