Abstract
IP3 is well established as being a mediator of calcium release from intracellular calcium stores. GTPγS (a stable analogue of GTP frequently used to activate GTP-binding proteins), however, has also been reported to cause calcium release and contractions in permeabilised rabbit main pulmonary artery (Kobayashi et al., 1988). We have previously reported (Allen & Carpenter, 1989) that inositol 1,4,5-trisphosphate (IP3) causes a contraction of saponin-permeabilised guinea-pig ileum longitudinal smooth muscle. Here we demonstrate that GTPγS also causes a contraction of permeabilised ileum longitudinal smooth muscle, though via a mechanism distinct from that of IP3.
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References
Allen, M.J. & Carpenter, J.R. (1989). Br. J. Pharmacol. 98, 792p.
Kobayashi, S., Somlyo, A.P. & Somlyo, A.V. (1988). J. Physiol. 403, 601–619.
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© 1992 Springer Science+Business Media New York
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Allen, M.J., Carpenter, J.R. (1992). IP3 and GTPγS Cause Contraction of Permeabilised Guinea Pig Ileum Longitudinal Smooth Muscle Via Distinct Mechanisms. In: Frank, G.B., Bianchi, C.P., ter Keurs, H.E.D.J. (eds) Excitation-Contraction Coupling in Skeletal, Cardiac, and Smooth Muscle. Advances in Experimental Medicine and Biology, vol 311. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3362-7_35
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DOI: https://doi.org/10.1007/978-1-4615-3362-7_35
Publisher Name: Springer, Boston, MA
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