Summary
Using the model of isolated myocytes, we have investigated under current- and/or voltage-clamp conditions: (i) the time-course of H2O2-induced changes in the action potentials and the contractility, (ii) the effect of pharmacological tools such as ryanodine, TTX and nifedipine on H2O2-induced changes; (iii) the effect H2O2 on ionic currents underlying the changes in APD; and (iv) the effect of deferoxamine on H2O2-induced changes.
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© 1992 Springer Science+Business Media New York
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Horackova, M., Beresewicz, A. (1992). Effect of Free Radicals on Excitation-Contraction Coupling in Isolated Rat and Guinea Pig Ventricular Myocytes. In: Frank, G.B., Bianchi, C.P., ter Keurs, H.E.D.J. (eds) Excitation-Contraction Coupling in Skeletal, Cardiac, and Smooth Muscle. Advances in Experimental Medicine and Biology, vol 311. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3362-7_28
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DOI: https://doi.org/10.1007/978-1-4615-3362-7_28
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