Abstract
It is well known that contraction and relaxation in skeletal muscle are regulated by Ca2+ release from and re-uptake by SR, and the latter to be an ATP-dependent Ca2+ pump (Ikemoto, 1982). On the other hand, release of Ca2+ is the key problem less well understood in E-C coupling, and the process occur in the absence of ATP, but not a simple reversal of Ca ion sequestration. In this study, we utilized a biphasic contracture of glycerinated fiber which showing an interaction of both processes. Thus, to assess the role of ATP in the mechanism of E-C coupling, effects of ryanodine, ruthenium red, nucleoside triphosphate (NTP), and the nonhydrolyzable ATP analog (AMP-PNP) on ATP- and Ca-induced contractures of glycerinated rabbit psoas muscle fiber were studied. Results suggest that ATP affects Ca release in the sarcoplasmic reticulum.
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© 1992 Springer Science+Business Media New York
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Tsujimoto, T. (1992). Effect of Ryanodine on Glycerinated Rabbit Psoas Muscle Fibers. In: Frank, G.B., Bianchi, C.P., ter Keurs, H.E.D.J. (eds) Excitation-Contraction Coupling in Skeletal, Cardiac, and Smooth Muscle. Advances in Experimental Medicine and Biology, vol 311. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3362-7_26
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DOI: https://doi.org/10.1007/978-1-4615-3362-7_26
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