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NPY-(18–36) and Pertussis Toxin Distinguish between the Negative and Positive Contractile Effects of Neuropeptide Y (NPY) in Ventricular Cardiomyocytes

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Excitation-Contraction Coupling in Skeletal, Cardiac, and Smooth Muscle

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 311))

Summary

The mechanism of action of NPY to produce contractions of adult rat ventricular myocytes was investigated. Positive effects were mediated through an L-type Ca2+ channel. Negative effects, linked through an inhibitory G-protein to a transient outward K+ channel, could be antagonised by NPY-(18–36).

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References

  1. J. Wharton, and S. Gulbenkian, Peptides in the mammalian cardiovascular system, Peptides 56: 292–316 (1989).

    CAS  Google Scholar 

  2. H.M. Piper, B.C. Millar, and B.J. McDermott, The negative inotropic effect of neuropeptide Y on the ventricular cardiomyocyte, Naunyn-Schmiedeberg's Arch. Pharmacol. 340: 333–337 (1989).

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  3. B.C. Millar, H.M. Piper, and B.J. McDermott, The anti-adrenergic effect of neuropeptide Y on the ventricular cardiomyocyte, Naunyn-Schmiedeberg’s Arch. Pharmacol. 338: 426–429 (1988).

    CAS  Google Scholar 

  4. M.R. Mitchell, T. Powell, D.A. Terrar, and V.W. Twist, Strontium, nifedipine and 4-aminopyridine modify the time course of the action potential in cells from rat ventricular muscle, Br. J. Pharmacol. 81: 551–556 (1984).

    Article  PubMed  CAS  Google Scholar 

  5. A. Balasubramaniam and S. Sheriff, Neuropeptide Y (18–36) is a competitive antagonist of neuropeptide Y in rat cardiac ventricular membranes, J. Biol. Chem. 265: 14724–14727 (1990).

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Author information

Authors and Affiliations

  1. Department of Therapeutics and Pharmacology, The Queen’s University of Belfast, UK

    B. Cherie Millar & Barbara J. McDermott

  2. Physiologisches Institut, Heinrich-Heine-Universitat, Dusseldorf, Germany

    H. Michael Piper

  3. Department of Surgery, University of Cincinnati, USA

    Ambikaipakan Balasubramaniam

  4. Pharmacologie Institut, Heinrich-Heine-Universitat, Dusseldorf, Germany

    Thomas Weis

Authors
  1. B. Cherie Millar
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  2. Barbara J. McDermott
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  3. H. Michael Piper
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  4. Ambikaipakan Balasubramaniam
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  5. Thomas Weis
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Editor information

Editors and Affiliations

  1. University of Alberta, Edmonton, Alberta, Canada

    George B. Frank

  2. Thomas Jefferson University, Philadelphia, Pennsylvania, USA

    C. Paul Bianchi

  3. University of Calgary, Calgary, Alberta, Canada

    Henk E. D. J. ter Keurs

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© 1992 Springer Science+Business Media New York

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Millar, B.C., McDermott, B.J., Piper, H.M., Balasubramaniam, A., Weis, T. (1992). NPY-(18–36) and Pertussis Toxin Distinguish between the Negative and Positive Contractile Effects of Neuropeptide Y (NPY) in Ventricular Cardiomyocytes. In: Frank, G.B., Bianchi, C.P., ter Keurs, H.E.D.J. (eds) Excitation-Contraction Coupling in Skeletal, Cardiac, and Smooth Muscle. Advances in Experimental Medicine and Biology, vol 311. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3362-7_25

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  • DOI: https://doi.org/10.1007/978-1-4615-3362-7_25

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6483-2

  • Online ISBN: 978-1-4615-3362-7

  • eBook Packages: Springer Book Archive

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