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The Significance of Na+ in E-C Coupling in Muscle

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Excitation-Contraction Coupling in Skeletal, Cardiac, and Smooth Muscle

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 311))

Abstract

A great diversity of forms of multicellular organisms having come into being during animal evolution has determined the exclusively structural and functional variety of their muscles differing, particularly, in their mode of activation. In vertebrate twitch muscles a crucial step in excitation- contraction (E-C) coupling concerns the mechanisms whereby the electrical activity of the T-tubular membrane (TTM) induces the release of Ca2+ from the sarcoplasmic reticulum (SR). The investigation of this key question of the E-C coupling has resulted in two principal hypotheses about the nature of the T-SR signal transmission: (i) Ca2+ release from SR triggered by a change in tubular membrane polarization and (ii) Ca2+ release induced by specific chemical transmitter from the T-system.

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Author information

Authors and Affiliations

  1. Sechenov Institute of Evolutionary Physiology and Biochemistry, Leningrad, USSR

    Vladimir Nesterov

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  1. Vladimir Nesterov
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Editor information

Editors and Affiliations

  1. University of Alberta, Edmonton, Alberta, Canada

    George B. Frank

  2. Thomas Jefferson University, Philadelphia, Pennsylvania, USA

    C. Paul Bianchi

  3. University of Calgary, Calgary, Alberta, Canada

    Henk E. D. J. ter Keurs

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© 1992 Springer Science+Business Media New York

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Nesterov, V. (1992). The Significance of Na+ in E-C Coupling in Muscle. In: Frank, G.B., Bianchi, C.P., ter Keurs, H.E.D.J. (eds) Excitation-Contraction Coupling in Skeletal, Cardiac, and Smooth Muscle. Advances in Experimental Medicine and Biology, vol 311. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3362-7_2

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  • DOI: https://doi.org/10.1007/978-1-4615-3362-7_2

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6483-2

  • Online ISBN: 978-1-4615-3362-7

  • eBook Packages: Springer Book Archive

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