Abstract
Considerable attention during the past few years has been given to phosphorylation of ion channels as a means whereby the activity of the ion channels can be regulated. This article will cover the evidence that cyclic nucleotides regulate the Ca2+ influx into the myocardial cells during each cardiac cycle and into vascular smooth muscle (VSM) cells. This regulation is presumable mediated by phosphorylation(s) of the Ca2+ slow channel protein and/or of associated regulatory protein(s). In myocardial cells, such phosphorylation (Fig. 1) presumably (a) increases the number of Ca2+ slow channels available for voltage activation during the action potential (AP); (b) increases the probability of their opening, and (c) increases their mean open time. A greater density of available Ca2+ channels increases Ca2+ influx and inward Ca2+ slow current (Isi) during the AP, and so increases the force of contraction of the heart. In some VSM cells, phosphorylation by cAMP-PK or cGMP-PK inhibits the Ca2+ slow channel activity and thereby produces vasodilation, whereas phosphorylation by PK-C stimulates the Ca2+ slow channel activity and produces vasoconstriction.
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Sperelakis, N., Tohse, N., Ohya, Y. (1992). Regulation of Calcium Slow Channels in Cardiac Muscle and Vascular Smooth Muscle Cells. In: Frank, G.B., Bianchi, C.P., ter Keurs, H.E.D.J. (eds) Excitation-Contraction Coupling in Skeletal, Cardiac, and Smooth Muscle. Advances in Experimental Medicine and Biology, vol 311. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3362-7_12
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