Abstract
Endothelial cell interaction with extracellular matrix proteins plays an important role in the maintenance of vascular wall integrity and in the formation of new vessels (Form et al.,1986; Ingberg and Folkman,1989).
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References
Albelda, S. M., and Buck, C. A.,1990, Integrins and other cell adhesion molecules, FASEB J., 4: 2868.
Albelda, S. M., Oliver, P. D., Romer, L. H. and Buck, C.A.,1990, EndoCAM: a novel endothelial cell-cell adhesion molecule. J.Cell Biol., 110: 1227.
Bar-Shavit, R., Sabbah, V., Lampugnani, M.G., Marchisio, P.C., Fenton II, J.W., Vlodaysky, I. and Dejana, E.,1991, An arg-gly-asp sequence within thrombin promotes endothelial cell adhesion, J.Cell Biol., 112:335.
Buck, C.A., Shea, E., Duggan, K. and Horwitz, A.F., 1986, Integrin (the CSAT antigen): functionality requires oligomeric integrity, J.Cell Biol., 103:2421.
Burridge, K.,1986, Substrate adhesions in normal and transformed fibroblasts: organization and regulation of cytoskeletal, membrane and extracellular matrix components at focal contacts, Cancer Rev., 4:18.
Burridge, K., Fath, K., Kelly, T., Nuckolis, G., and Turner, C., 1988, Focal adhesions transmembrane junctions between the extracellular matrix and the cytoskeleton, Ann Rev.Cell Biol., 4:487.
Carter, W. G., Wayner, E. A., Bouchard, T. S., and Kaur, P.,1990, The role of integrins a2b1 and a3b1 in cell-cell and cell-substrate adhesion of human epidermal cells, J.Cell Bio1.,110:1387.
Cheresh, D., 1987, Human endothelial cells synthesize and express an arg-gly-asp-directed adhesion receptor involved in attachment to fibrinogen and von Willebrand factor, pron.Natl.Acad.Sci. USA, 84:6471.
Conforti, G., Zanetti, A., Colella, S., Abbadini, M., Marchisio, P.C., Pytela, R., Giancotti, F., Tarone, G., Languino, L.R., and Dejana, E., 1989, Interaction of fibronectin with cultured human endothelial cells: characterization of the specifid receptor., Blood, 73:1576.
Conforti, G., Zanetti, A., Pasquali-Ronchetti, I., Quaglino Jr., D., Neyroz, P., and Dejana, E., 1990, Modulation of vitronectin receptor binding by membrane lipid composition, J.Biol.Chem., 265: 4011.
Dejana, E., Colella, S., Languino, L.R., Balconi, G., Corbascio, G.C., and Marchisio, P.C., 1987, Fibrinogen induces adhesion, spreading and microfilament organization of human endothelial cells in vitro, J.Cell Biol.. 104:1403.
Dejana, E., Colella, S., Conforti, G., Abbadini, M., Gaboli M., and Marchisio, P.C., 1988, Fibronectin and vitronectin regulate the organization of their respective arg-gly-asp adhesion receptors in cultured human endothelial cells, J.Cell Biol., 107:1215.
Dejana, E., Lampugnani, M.G., Giorgi, M., Gaboli, M., Federici, A.B., Ruggeri, Z.M., and Marchisio, P.C., 1989, von Willebrand factor promotes endothelial cell adhesion via an arg-gly-asp dependent mechanism, J.Cell Riol., 109:367.
Dejana, E., Lampugnani, M.G., Giorgi, M., Gaboli, M., and Marchisio, P.C., 1990, Fibrinogen induces endothelial cell adhesion and spreading via the release of endogenous matrix proteins and the recruitment of more than one integrin receptor, Blood, 75: 1509.
Dejana, E., and Lauri, D., 1990, Biochemical and functional characteristics of integrins: a family of adhesive receptors present in hematopoietic cells, Haematologica,75:1.
De Luca, M., Tamura, R.N., Kajiji, S., Bondanza, S., Rossino, P., Cancedda, R., Marchisio, P.C., and Quaranta, V., 1990, Polarized integrin mediates human keratinocyte adhesion to basal lamina, Proc.Natl.Acad.Sci. USA, 87:6888.
Elices, M. J., and Hemler, M.E., 1989, The human integrin VLA-2 is a collagen receptor on some cells and a collagen/laminin receptor on others, Proc.Natl.Aoad.Soi. USA 86:9906.
Form, D.M., Pratt, B.M., and Madri, J. A.,1986, Endothelial cell proliferation during angiogenesis. In vitro modulation by basement membrane components, Lab. Invest. 55:521.
Gailit, J., and Ruoslahti, E., 1988, Regulation of the fibronectin receptor affinity by divalent cations, J Bip1. Chem. 263:12927.
Ginsberg, M. H., Loftus, J. C., and Plow, E. F., 1988, Cytoadhesins, integrins, and platelet, Thromb. Haemostasis, 59:1.
Gougos, A., and Letarte, M., 1990, Primary structure of endoglin, an RGD-containing glycoproteins of human endothelial cells, J.Biol.Chem. 265:8361.
Hayashi, Y., Haimovich, B., Reszka, A., Boettiger D., and Horwitz, A.,1990, Expression and function of chicken integrin (31 subunit and its cytoplasmic domain mutants in mouse NIH 3T3 cells, J.Ce11 Biol., 110:175.
Heimark, R. L., Degner, M., and Schwartz, S.M., 1990, Identification of a Ca2+-dependent cell-cell adhesion molecule in endothelial cells J.Cell Biol., 110:1745.
Hemler, M. E., 1990, VLA proteins in the integrin family: structures, functions and their role on leukocytes, Annu. Rev. Immunol. 8: 365.
Hynes, R.O., 1987, Integrins: a family of cell surface receptors, Cell 48: 549.
Ingber, D. E., and Folkman, J., 1989, How does extracellular matrix control capillary morphogenesis,Cell, 58:803.
Ingber, D. E., 1990, Fibronectin controls capillary endothelial cell growth by modulating cell shape, Proc.Nafl.Acad.Sci. USA, 87:3579.
Ingber, D. E., Prusty, D., Frangioni, J. V., Cragoe, Jr E. J., Lechene, C., and Schwartz, M.A., 1990, Control of intracellular pH and growth by fibronectin in capillary endothelial cells, J.Cell Biol.. 110: 1803.
Isberg, R. R., and Leong, J.M., 1990, Multiple ßl chain integrins are receptors for invasin, a protein that promotes bacterial penetration into mammalian cells, Cell, 60:861.
Kramer, R. H., Cheng, Y.-F., and Clyman, R., 1990, Human microvascular endothelial cells use ß1 and ß3 integrin receptor complexes to attach to laminin, J.Cell Biol., 111:1233.
Lampugnani, M. G., Giorgi, M., Gaboli, M., Dejana, E., and Marchisio, P.C., 1990, Endothelial cell motility, integrin receptor clustering, and microfilament organization are inhibited by agents that increase intracellular cAMP, Lab. Invest., 63:521.
Lampugnani, M. G., Resnati, M., Dejana, E., and Marchisio, P.C., 1991, The role of integrins in the maintenance of endothelial monolayer integrity, J.Cell Biol., 112:479.
Languino, L. R., Gehlsen, K.R., Wayner, E., Carter, W.G., Engvall, E., and Ruoslahti, E., 1989a, Endothelial cells use a2ßlintegrin as a laminin receptor, J.Cell Biol, 109:2455.
Languino, L. R., Colella, S., Zanetti, A., Andrieux, A., Ryckewaert, J. J., Charon, M.H., Marchisio, P.C., Plow, E.F., Ginsberg, M.H., Marguerie, G., and Dejana, E., 1989b, Fibrinogen-endothelial cell interaction in vitro: a pathway mediated by an arg-gly-asp recognition specificity, Blood, 73: 734.
Larjava, H., Peltonen, J., Akiyama, S. K., Yamada, S. S., Gralnick, H.R., Uitto, J., and Yamada K.M., 1990, Novel function for ß1 integrins in keratinocyte cell-cell interactions, J.Cell Biol, 110:803.
Lawler, J., Weinstein, R., and Hynes, R. O., 1988, Cell attachment to thrombospondin: the role of arg-gly-asp, calcium, and integrin receptors, J.Cell Biol., 107: 2351.
Marchisio, P. C., 1991, Integrins and tissue organization, Progr. in Neuroimmunol. in press.
Newman, P. J., Berndt, M. C., Gorski, J., White II, G. C., Lyman, S., Paddock, C., and Muller, W. A., 1990, PECAM-1 (CD31) cloning and relation to adhesion molecules of the immunoglobulin gene superfamily Science, 247:1219.
Pytela, R., Pierschbacher M.D., and Ruoslahti, E.,1985, Identification and isolation of a 140 kd cell surface glycoprotein with properties expected of a fibronectin receptor, Cell. 40:191.
Ruoslahti, E., and Pierschbacher, M.D., 1987, New perspectives in cell adhesion: RGD and integrins, Science 238:491.
Ruoslahti, E., and Giancotti, F.G., 1989, Integrins and tumor cell dissemination, Cancer Cells, 1:119.
Simmons, D., Walker, C., Power C., and Piggott, R., 1990, Molecular cloning of CD31, a putative intercellular adhesion molecule closely related to carcinoembryonic antigen, J. Exp, Med., 171: 2147.
Singer, I. I., Scott, S., Kawka, D.W., Kazazis, D.M., Gailit, J., and Ruoslahti, E., 1988, Cell surface distribution of fibronectin and vitronectin receptors depends on substrate composition and extracellular matrix accumulation, J.Cell Biol..106:2171.
Smith, J. W., Vestal, D. J., Irwin, S.V., Burke, T.A., and Cheresh, D.A.,1990, Purification and functional characterization of integrin αvβ5. An adhesion receptor for vitronectin, J Biel Chem., 265:11008.
Solowska, J., Guan, J.-L., Marcantonio, E. E., Trevithick, J. E., Buck, C.A., and Hynes, R. O.,1989, Expression of normal and mutant avian integrin subunits in rodent cells, J.Cell Biol.,109:853.
Sonnenberg, A., Modderman, P.W., and Hogervost, F.,1988, Laminin receptor on platelets is the integrin VLA-6, Nature, 336:487.
Springer, T. A., 1990, Adhesion receptors of the immune system, Nature, 346:425.
Tranqui, L., Andrieux, A., Hudry-Clergeon, G., Ryckewaert, J. J., Soyez, S., Chapel, A., Ginsberg, M. H., Plow, E. F., and Marguerie, G.,1989, Differential structural requirements for fibrinogen binding to platelets and to endothelial cells, J.Cell Biol., 108:2519.
van Mourik, J. A., von dem Borne A. E. G. Kr., and Giltay, J.G., 1990, Pathophysiological significance of integrin expression by vascular endothelial cells, Biochem. Pharm.. 39:233.
Vedder, N. B., and Harlan, J. M.,1988, Increased surface expression of CD11b/CD18 (MAC-1) is not required for stimulated neutrophil adherence to cultured endothelium, J. Clin. Invest.. 81:676.
Wayner, E. A., and Carter, W.G.,1987, Identification of multiple cell adhesion receptors for collagen and fibronectin in human fibrosarcoma cells possessing unique a and common β subunit, J.Cell Biol., 105:1873.
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Dejana, E., Zanetti, A., Dominguez-Jimenez, C., Conforti, G. (1992). Role of Integrins in Endothelial Cell Function. In: Maragoudakis, M.E., Gullino, P., Lelkes, P.I. (eds) Angiogenesis in Health and Disease. NATO ASI Series, vol 227. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3358-0_8
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