Abstract
Basic fibroblast growth factor (bFGF) belongs to a class of heparin-binding growth factors which includes acidic FGF (aFGF) and five other related oncogene products (Burgess and Maciag, 1989). bFGF induces cell proliferation in a variety of cell types of mesodermal and neuro-ectodermal origin and appears to be a trophic factor for cultured neuronal cells. In vivo, bFGF may play a role in embryonic development (Kimelman and Kirschner, 1987) and induces neovascularization in different angiogenesis assays (Folkman and Klagsbrun, 1987). Also, anti-bFGF antibodies have been shown to inhibit angiogenesis in normal wound repair, indicating that bFGF is intrinsically involved in normal neovascularization (Broadley et al., 1989).
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Akiyama, T., Ishida, J., Nakagawa, S., Ogawara, H., Watanabe, S., Itoh, N., Shibuya, M., and Fukami, Y., 1987, Genistein, a specific inhibitor of tyrosine-specific protein kinases, J. Biol. Chem., 262:5592.
Baird, A., Schubert, D., Ling, N., and Guillemin, R., 1988, Receptor-and heparin-binding domains of basic fibroblast growth factor, Proc. Natl. Acad. Sci. U.S.A., 85:2324.
Bouche, G., Gas, N., Prats, H., Baldin, V., Tauber, J. P: Teissie, J., and Amalric, F., 1987, Basic fibroblast growth factor enters the nucleolus and stimulates the transcription of ribosomal genes in ABAE cells undergoing Go-G1 transition, Proc. Natl. Acad. Sci. U.S.A., 84:6770.
Broadley, K. N., Aquino, A. M., Woodward, S. C., BuckleySturrock, A., Sato, Y., Rifkin, D. B., and Davidson, J. M., 1989, Monospecific antibodies implicate basic fibroblast growth factor in normal wound repair, Lab. Invest., 61:571.
Burgess, W. H., and Maciag, T., 1989, The heparin-binding (fibroblast) growth factor family of proteins, Annu. Rev. Biochem., 58:575.
Burgess, W. H., Dionne, C. A., Kaplow, J., Mudd, R., Friesel, R., Zilberstein, A., Schlessinger, J., and Jaye, M., 1990a, Characterization and cDNA cloning of phospholipase C-gamma, a maior substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase, Mol. Cell. Biol., 10:4770.
Burgess, W. H., Shaheen, A. M., Rayera, M., Jaye, M., Donohue, P. J., and Winkles, J. A., 1990b, Possible dissociation of the heparin-binding and mitogenic activities of heparin-binding (acidic fibroblast) growth factor-1 from its receptor-binding activities by site-directed mutagenesis of a single lysine residue, J. Cell Biol., 111:2129.
Coffey, R. J., Leof, E. B., Shipley, G. D., and Moses, H. L., 1987, Suramin inhibition of growth factor receptor binding and mitogenicity in AKR-2B cells, J. Cell. Physiol., 132:143.
Folkman, J., 1985, Tumor angiogenesis, Adv. Cancer Res., 43:175.
Folkman, J., and Klagsbrun, M., 1987, Angiogenic factors, Science, 235:442.
Hidaka, H., Inagaki, M., Kawamoto, S., and Sasaki, Y., 1984, Isoquinolinesulfonamides, novel and potent inhibitors of cyclic nucleotide dependent protein kinase and kinase C, Biochemistry, 23:5036.
Imamura, T., Englera, K., Zhan, X., Tokita, Y., Forough, R., Roeder, D., Jackson, A., Maier, J. A. M., Hla, T., and Maciag, T., 1990, Recovery of mitogenic activity of a growth factor mutant with a nuclear translocation sequence, Science, 249:1567.
Isacchi, A., Statuto, M., Chiesa, R., Bergonzoni, L., Rusnati, M., Sarmientos, P., Ragnotti, G., and Presta, M., 1991, A 6-amino acid deletion in basic fibroblast growth factor dissociates its mitogenic activity from its plasminogen activator-inducing capacity, Proc. Natl. Acad. Sci. U.S.A., 88:2628.
Kimelman, D., and Kirschner, M., 1987, Synergistic induction of mesoderm by FGF and TGF-beta and the identification of an mRNA coding for FGF in the early Xenopus embryo, Cell, 51:869.
Lee, P. L., Johnson, D. E., Cousens, L. S., Fried, V. A., and Williams, L. T., 1989, Purification and complementary DNA cloning of a receptor for basic fibroblast growth factor, Science, 245:57.
Maier, J. A. M., Presta, M., and Ragnotti, G., 1989, Induction of plasminogen activator activity by phorbol ester in transformed fetal bovine aortic endothelial cells. Possible independence from protein kinase C, Biochem. Biophys. Res. Commun., 160:682.
Mignatti, P., Tsuboi, R., Robbins, E., and Rifkin, D. B., 1989, In vitro angiogenesis on the human amniotic membrane: requirement for basic fibroblast growth factor-induced proteinases, J. Cell Biol., 108:671.
Montesano, R., Pepper, M. S., Belin, D., Vassalli, J. D., and Orci, L., Induction of angiogenesis in vitro by vanadate, an inhibitor of phosphotyrosine phosphatases, 1988, J. Cell. Physiol., 134:460.
Moscatelli, D., Presta, M., and Rifkin, D.B., 1986, Purification of a factor from human placenta that stimulates capillary endothelial cell protease production, DNA synthesis, and migration, Proc. Natl. Acad. Sci. U.S.A., 83:2091.
Nishibe, S., Wahl, M. I., Hernandez-Sotomayor, S. M. T., Tonks, N. K., Rhee, S. G., and Carpenter, G., 1990, Increase of the catalytic activity of phospholipase C-gamma 1 by tyrosine phosphorylation, Science, 250:1253.
Nishizuka, Y., 1986, Studies and perspectives of protein kinase C, Science, 233:305.
Pepper, M. S., Belin, D., Montesano, R., Orci, L., and Vassalli, J. D., 1990, Transforming growth factor-beta 1 modulates basic fibroblast growth factor-induced proteolytic and angiogenic properties of endothelial cells in vitro,J. Cell Biol., 111:743.
Presta, M., Moscatelli, D., Joseph-Silverstein, J., and Rifkin, D. B., 1986, Purification from a human hepatoma cell line of a basic fibroblast growth factor-like molecule that stimulates capillary endothelial cell plasminogen activator production, DNA synthesis, and migration, Mol. Cell. Biol., 6:4060.
Presta, M., Maier, J. A. M., Rusnati, M., and Ragnotti, G.,1989a, Basic fibroblast growth factor: production, mitogenic response, and post-receptor signal trasduction in cultured normal and transformedfetal bovine aortic endothelial cells, J. Cell. Physiol., 141:517.
Presta, M., Maier, J. A. M., and Ragnotti, G., 1989b, The mitogenic signalling pathway but not the plasminogen activator-inducing pathway of basic fibroblast growth factor is mediated through protein kinase C in fetal bovine aortic endothelial cells, J. Cell Biol., 109:1877.
Rasmussen, H., 1986, The calcium messenger system, N. Engl. J. Med., 314:1094.
Ruta, M., Burgess, W., Givol, D., Epstein, J., Neiger, N., Kaplow, J., Crumley, G., Dionne, C., Jaye, M., and Schlessinger, J., 1989, Receptor for acidic fibroblast growth factor is related to the tyrosine kinase encoded by the fms-like gene (FLG), Proc. Natl. Acad. Sci. U.S.A., 86:8722.
Saksela, O., Moscatelli, D., and Rifkin, D. B., 1987, The opposing effects of basic fibroblast growth factor and transforming growth factor beta on the regulation of plasminogen activator activity in capillary endothelial cells, J. Cell Biol., 105:957.
Yamashita, T., Sakai, M., Kawai, Y., Aono, M., and Takahashi, K., 1989, A new activity of herbimycin A: inhibition of angiogenesis, J. Antibiotics, 42:1015.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1992 Springer Science+Business Media New York
About this chapter
Cite this chapter
Presta, M. et al. (1992). Basic Fibroblast Growth Factor and Endothelial Cells: Receptor Interaction, Signal Transduction, Cellular Response-Dissociation of the Mitogenic Activity of bFGF from its Plasminogen Activator-Inducing Capacity. In: Maragoudakis, M.E., Gullino, P., Lelkes, P.I. (eds) Angiogenesis in Health and Disease. NATO ASI Series, vol 227. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3358-0_7
Download citation
DOI: https://doi.org/10.1007/978-1-4615-3358-0_7
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-6481-8
Online ISBN: 978-1-4615-3358-0
eBook Packages: Springer Book Archive