Abstract
Endothelial cell turnover within normal adult tissues generally appears to be very low and is in the range of months or even years (Denekamp, 1984). In contrast, the proliferation rate of endothelial cells lining the blood vessels that are involved in tumor vascularization is very high and in the range of a few days (Engermann et al., 1967). The massive formation of new blood vessels is not an exclusive characteristic of tumor development, but also occurs in other pathological conditions like diabetic retinopathies or rheumatoid arthritis. It can also be observed during wound healing as well as during ovulation and corpus luteum formation in the female adult, but in these instances the angiogenic process seems to be regulated by control mechanisms that prevent an overshooting reaction. This controlled angiogenic process may be termed physiological angiogenesis to distinguish it from the aberrant formation of blood vessels under various pathological conditions.
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References
Bär, T. (1980). The Vascular Sytem of the Cerebral Cortex. Springer Verlag. Heidelberg.
Böhlen, P., Esch, F., Baird, A. and Gospodarowicz, D. (1985). Acidic fibroblast growth factor (FGF) from bovine brain: amino-terminal sequence and comparison with basic FGF. EMBO J. 4: 1951–1956.
Clark, E.R. and Clark, E.L. (1939).Microscopic observations on the growth of blood capillaries in the living mammal. Am. J. Anat. 64: 251–301.
Denekamp, J. (1984).Vascular endothelium as the vulnerable element in tumors. Acta Radiol. Oncol. 23: 217–217
Doetschman, T.C., Eistetter, H., Katz, M., Schmidt, W. and Kemöer, R. (1985). The in vivo development of blastocystderived embryonic stem cell lines: formation of visceral yolk sac, Blood islands and myocardium. J. Embryol. exp. Morphol. 87: 27–45.
Ekblom, P., Sariola, H., Karkinen, M. and Saxen, L. (1982). The origin of the glomerular endothelium. Cell Differ. 11: 35–39.
Engermann, R. L., Pfaffenbach, D. and Davis, M. D. (1967). Cell turnover of capillaries. Lab. Invest. 17: 738–743.
Feinberg, R. N., Latker, C. H. and Beebe, D. C. (1986). Localized vascular regression during limb morphogenesis in the chicken embryo. I. Spatial and temporal changes in the vascular pattern. Anat. Rec. 214: 405–409.
Ferrara, N. and Henzel, W. J. (1989). Pituitary follicular cells secrete a novel heparin-binding growth factor specific for vascular endothelial cells. Biochem. Biophys. Res. Comm. 161: 851–858.
Flamme, I. (1989). Is extraembryonic angiogenesis in the chick embryo controlled by the endoderm. Anat. Embryol. 180: 259–272.
Gospodarowicz, D., Cheng, J., Lui, G., Baird, A. and Böhlen, P. (1984). Isolation of brain fibroblast growth factor by heparin-sepharose affinty chromatography: identity with pituitary fibroblast growth factor. Proc. Natl. Acad. Sci. USA 81: 6963–6967.
Gospodarowicz, D. and Lau, K. (1989). Pituitary follicular cells secrete both vascular endothelial growth factor and follistatin. Biochem. Biophys. Res. Comm. 165: 292–298.
Haar, J.L. and Ackermann, G.A. (1971). A phase and electron microscopic study of vasculogenesis and.erythropoiesis in the yolk sac of the mouse. Anat. Rec. 170: 199–224.
Hallmann, R., Feinberg, R. N., Latker, C. H., Sasse, J. and Risau, W. (1987). Regression of bloodvessels precedes cartilage differentiation during chick limb development. Differentiation 34: 98–105.
Heuer, J. G., von Bartheld, C. S., Kinoshita, Y., Evers, P. C. and Bothwell, M. (1990). Alternating phases of FGF receptor and NGF receptor expression in the developing chicken nervous system. Neuron 5: 283–296.
Hurle, J. M., Colvee, E. and Fernendez-Teran, M. A. (1985). Vascular regression during the formation of the free digits in the avian limb bud: a comparativ study in chick and duck embryos J. Embryol. exp. Morph. 85: 239–250.
Ishikawa, F., Miyazonz, K., Hellman, U., Drexler, H., Wernstedt, C., Hagiwara, K., Usuki, K., Takaku, F., Risau, W. and Heldin, C.-H. (1989). Identification of angiogenic activity and the cloning and expression of platelet-derived endothelial growth factor. Nature 338: 557–562.
Keck, P. J., Hauser, S. D., Krivi, G., Sanzo, K., Warren, T., Feder, J. and Connolly, D. T. (1989). Vascular permeability factor, an endothelial cell mitogen related to PDGF. Science 246: 1309–1312.
Lobb, R. R. and Fett, J. W. (1984). Purification of two distinct growth factors from bovine neural tissue by eparin affinty chromatography. Biochem. 23: 6265–6299.
Montesano, R., Pepper, M. S., Möhle-Steinlein, U., Risau, W., Wagner, E. F. and Orci, L. (1990). Increased proteolyticctivity is responsible for the aberrant morphogenetic behaviour of endothelial cells expressing the middle T oncogen. Cell 62: 435–445.
Olwin, B. B. and Hauschka, S. D. (1990). Fibroblast growth factor receptor level decrease during chick embryogenesis. J. Cell Biol. 110: 503–509.
Pardanaud, L., Yassine, F. and Dieterlen-Lievre, F. (1989).Relationship between vasculogenesis, angiogenesis and haemopoesis during avian ontogeny. Development 105: 473–485.
Poole, T.J. and Coffin, J.D. (1989). Vasculogenesis and angiogenesis - two different mechanisms establish embryonic vascular pattern. J. Exp. Zool. 251: 224–231.
Risau, W. (1986). Developing brain produces an angiogenesis factor. Proc. Natl. Acad. Sci. USA 83: 3855–3859.
Risau W. and Lemmon, V. (1988). Changes in the vascular extracellular matrix during embryonic vasculogenesis and angiogenesis. Devl. Biol. 125: 441–450.
Risau, W., Sariola, H., Zerwes, H.-G., Sasse, J., Ekblom, P., Kemler, R. and Doetschman, T. (1988a). Vasculogenesis and angiogenesis in embryonic-stem-cell-derived embryoid bodies. Development 102: 471–478.
Risau, W., Gautschi-Sova, P., Böhlen, P. (1988b). Endothelial cell growth factors in embryonic and adult chick brain are related to human acidic fibroblast growth factors. EMBO J. 7: 959–962.
Sabin, F.R. (1917). Origin and development of the primitive vessels of the chick and of the pig. Carnegie Contrib. Ebryol. 6: 61–124.
Schnürch, H. and Risau, W. (1991). Differentiating and mature neurons express the acidic fibroblast growth factor gene during chick neural development. Development 111: 1143–1154.
Stewart, P.A. and Wiley, M.J. (1981). Developing nervous tissue induces the formation of blood brain barrier characteristics in invading endothelial cells: A study using quail-chick translpantation chimeras. Devl. Biol. 84: 183–192.
Usuki, K., Norberg, L., Larsson, E., Miyazono, K., Hellman, U., Wernstedt, C., Rubin, K. and Heldin, C.-H. (1990). Localisation of platelet-derived endothelial cell growth factor in human placenta and purification of an alternatively processed form. Cell Regulation 1: 577–596.
Wanaka, A., Milbrandt, J. and Johnson, E.M. (1991). Expression of FGF receptor gene in rat development. Development 111:455–468.
Williams, R. L., Courneidge, S. A. and Wagner, E. F. (1988). Embryonic lethalities and endothelial tumors in chimeric mice expressing polyoma middle T oncogene. Cell 52: 121–131.
Williams, R. L., Risau, W., Zerwes, H.-G., Drexler, H., Aguzzi, A. and Wagner, E. F. (1989). Endothelioma cells expressing the polyoma middle T oncogene induce hemangiomas by host cell recruitment. Cell 57: 1053–1063.
Zhan, X., Bates, B., Hu, X. and Goldfarb, M. (1988). The human FGF-5 oncogene encodes a novel protein related to fibroblast growth factors. Mol. Cell. Biol. 8:3487–3495.
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© 1992 Springer Science+Business Media New York
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Drexler, H., Schnürch, H., Breier, G., Risau, W. (1992). Regulation of Embryonic Blood Vessel Formation. In: Maragoudakis, M.E., Gullino, P., Lelkes, P.I. (eds) Angiogenesis in Health and Disease. NATO ASI Series, vol 227. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3358-0_2
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DOI: https://doi.org/10.1007/978-1-4615-3358-0_2
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