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Angiogenesis in Health and Disease pp 195–206Cite as

Vascular Growth in the Intermittently Ischemic Heart: A Study on Growth Factors Expression

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Part of the book series: NATO ASI Series ((NSSA,volume 227))

Abstract

The formation of blood vessels, i.e. angiogenesis, is an important component of various normal and pathological conditions including wound healing, fracture repair and in females during follicle development, ovulation and pregnancy. Under normal physiological conditions, angiogenesis is tightly regulated, whereas during pathological conditions such as tumor growth and retinopathies it seems to be uncontrolled. Various methods including corneal micropocket and chick embryo chorioallantoic membrane assay have been described to study angiogenesis in vivo. New capillaries originated mainly from sprouting of small venulesand localized degradation of basement membrane of the parent venule was followed by movement of endothelial cells towards the angiogenic stimulusl. Angiogenesis involves the orderly migration, proliferation and differentiation of vascular cells2. The mechanism of angiogenesis and endothelial cell growth control, especially with respect to collateralization (collateral vessel development) is an important research area of cardiovascular physiology.

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Author information

Authors and Affiliations

  1. Max-Planck-Institute for Physiological and Clinical Research, 6350-Bad, Nauheim, Germany

    Hari S. Sharma, Martin Wünsch, Stefan Sack & Wolfgang Schaper

Authors
  1. Hari S. Sharma
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  2. Martin Wünsch
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  3. Stefan Sack
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  4. Wolfgang Schaper
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Editor information

Editors and Affiliations

  1. University of Patras Medical School, Patras, Greece

    Michael E. Maragoudakis

  2. University of Turin Medical School, Turin, Italy

    Pietro Gullino

  3. University of Wisconsin Medical School, Milwaukee, Wisconsin, USA

    Peter I. Lelkes

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© 1992 Springer Science+Business Media New York

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Sharma, H.S., Wünsch, M., Sack, S., Schaper, W. (1992). Vascular Growth in the Intermittently Ischemic Heart: A Study on Growth Factors Expression. In: Maragoudakis, M.E., Gullino, P., Lelkes, P.I. (eds) Angiogenesis in Health and Disease. NATO ASI Series, vol 227. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3358-0_18

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  • DOI: https://doi.org/10.1007/978-1-4615-3358-0_18

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6481-8

  • Online ISBN: 978-1-4615-3358-0

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